Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis

P Mahavadi, I Henneke, C Ruppert… - Toxicological …, 2014 - academic.oup.com
Amiodarone (AD) is a highly efficient antiarrhythmic drug with potentially serious side effects.
Severe pulmonary toxicity is reported in patients receiving AD even at low doses and may …

A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the …

MD Taylor, K Van Dyke, LL Bowman, PR Miles… - Toxicology and applied …, 2000 - Elsevier
Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to …

Regulation of macroautophagy in amiodarone‐induced pulmonary fibrosis

P Mahavadi, L Knudsen, S Venkatesan… - The Journal of …, 2015 - Wiley Online Library
Amiodarone (AD) is an iodinated benzofuran derivative, especially known for its
antiarrhythmic properties. It exerts serious side‐effects even in patients receiving low doses …

Intratracheal amiodarone administration to F344 rats directly damages lung airway and parenchymal cells

MD Taylor, JM Antonini, JR Roberts, SS Leonard… - Toxicology and applied …, 2003 - Elsevier
Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. We previously reported a model …

Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells

AC Nicolescu, Y Ji, JL Comeau, BC Hill… - Toxicology and applied …, 2008 - Elsevier
Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM …

[PDF][PDF] Amiodarone attenuates apoptosis, but induces phospholipidosis in rat alveolar epithelial cells

E Kapatou, A Skyrlas, MG Agelaki, C Pantos… - Journal of physiology …, 2010 - jpp.krakow.pl
Amiodarone-induced pulmonary toxicity is a serious side-effect, but the underlying
molecular mechanisms remain unclear. We examined phospholipidosis and apoptosis in rat …

A Mechanistic Study on the Amiodarone‐Induced Pulmonary Toxicity

B Al-Shammari, M Khalifa, SA Bakheet… - … medicine and cellular …, 2016 - Wiley Online Library
Amiodarone‐(AM‐) induced pulmonary toxicity (AIPT) is still a matter of research and is
poorly understood. In attempting to resolve this issue, we treated Sprague‐Dawley rats with …

The inhibitory mechanisms of losartan and vitamin D on amiodarone‐induced lung inflammation in rats: Role of mitogen‐activated protein kinases/activator protein‐1

S Al‐Hassan, H Attia, H Alomar… - Journal of Biochemical …, 2021 - Wiley Online Library
Amiodarone (AMD), an antiarrhythmic drug, is used cautiously due to its lung toxicity that is
characterized by alveolar inflammation followed by fatal fibrosis. AMD induces lung …

Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes

A Baritussio, S Marzini, M Agostini… - … of Physiology-Lung …, 2001 - journals.physiology.org
Amiodarone may induce lung damage by direct toxicity or indirectly through inflammation.
To clarify the mechanism of direct toxicity, we briefly exposed rabbit alveolar macrophages …

Amiodarone induces epithelial-mesenchymal transition in A549 cells via activation of TGF-β1

J Weng, H Chen, H Wu, M Tu, Z Wang… - Drug and Chemical …, 2020 - Taylor & Francis
Amiodarone is a high effectiveness anti-arrhythmia agent which is able to induce pulmonary
fibrosis. Many studies have shown that the epithelial-mesenchymal transition (EMT) was a …