Therapeutic potential of indole alkaloids in respiratory diseases: A comprehensive review

S Mitra, SR Prova, SA Sultana, R Das, F Nainu… - Phytomedicine, 2021 - Elsevier
Background Indole alkaloids are very promising for potential therapeutic purposes and
appear to be particularly effective against respiratory diseases. Several experimental studies …

Indole alkaloids from leaves of Alstonia scholaris (L.) R. Br. protect against emphysema in mice

YL Zhao, ZF Yang, BF Wu, JH Shang, YP Liu… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Alstonia scholaris (L.) R. Br.(Apocynaceae) is a medicinal
plant in China traditionally used to treat pulmonary diseases, including bronchitis, whooping …

[HTML][HTML] Acute and Chronic Toxicity of Indole Alkaloids from Leaves of Alstonia scholaris (L.) R. Br. in Mice and Rats

YL Zhao, M Su, JH Shang, X Wang… - Natural products and …, 2020 - Springer
Abstract Alstonia scholaris (L.) R. Br.(Apocynaceae) is an evergreen tree that has been used
to treat lung diseases. In this study, the toxicity profile of indole alkaloids from leaves of A …

Pharmacokinetics and safety evaluation in healthy Chinese volunteers of alkaloids from leaf of Alstonia scholaris: a multiple doses phase I clinical trial

R Li, MJ Zi, ZP Gou, YL Zhao, WT Zhang, F Lu, WY Cao… - Phytomedicine, 2019 - Elsevier
Abstract Background Alstonia scholaris (Apocynaceae) was reported to be a rich source of
indole alkaloids, which exhibited remarkably bioactivities. The leaf of A. scholaris has been …

[HTML][HTML] Acute and Sub-chronic Toxicity of Indole Alkaloids Extract from Leaves of Alstonia scholaris (L.) R. Br. in Beagle Dogs

YL Zhao, M Su, JH Shang, X Wang, GL Bao… - Natural Products and …, 2020 - Springer
Abstract Alstonia scholaris (L.) R. Br., an evergreen tropical plant rich in indole alkaloids with
significant physiological activity, is traditionally used to treat respiratory diseases in China …

Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice

YL Zhao, ZF Yang, JH Shang, WY Huang… - Journal of …, 2018 - Elsevier
Abstract Ethnopharmacological relevance Leaf of Alstonia scholaris (L.) R.
Br.(Apocynaceae), a wide used ethic-medicine in many Asia and Africa counties, has also …

[HTML][HTML] Genotoxicity and Safety Pharmacology Studies of Indole Alkaloids Extract from Leaves of Alstonia scholaris (L.) R. Br.

YL Zhao, M Su, JH Shang, X Wang, GL Bao… - Natural Products and …, 2020 - Springer
Indole alkaloids extract (IAAS) was prepared from leaves of Alstonia scholaris (L.) R. Br., an
evergreen tropical plant widely distributed throughout the world. This plant has been used …

Pharmacological effects of indole alkaloids from Alstonia scholaris (L.) R. Br. on pulmonary fibrosis in vivo

YL Zhao, SB Pu, Y Qi, BF Wu, JH Shang, YP Liu… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Alstonia scholaris (L.) R. Br.(Apocynaceae) is a Dai folk
medicine for the treatment of lung diseases in China. Aim of the study: The present study …

Airways antiallergic effect and pharmacokinetics of alkaloids from Alstonia scholaris

YL Zhao, J Cao, JH Shang, YP Liu, A Khan, HS Wang… - Phytomedicine, 2017 - Elsevier
Abstract Background Alstonia scholaris (L.) R. Br.(Apocynaceae), an important herbal
medicine, has been widely used to treat respiratory tract diseases, such as cough, asthma …

Effect of total alkaloids from Alstonia scholaris on airway inflammation in rats

YL Zhao, JH Shang, SB Pu, HS Wang, B Wang… - Journal of …, 2016 - Elsevier
Abstract Ethnopharmacological relevance Alstonia scholaris (Apocynaceae) have been
traditionally used for treatment of respiratory diseases in “dai” ethnopharmacy for hundreds …