Synthesis, crystal structure and Hirshfeld Surface analysis of benzamide derivatives of thiourea as potent inhibitors of α-glucosidase in-vitro
Benzamide based structural analogues 1–15 were synthesized, and evaluated for α-
glucosidase inhibition activity in vitro for the first time. Compounds 1–9 were found to be …
glucosidase inhibition activity in vitro for the first time. Compounds 1–9 were found to be …
Synthesis, molecular docking studies of hybrid benzimidazole as α-glucosidase inhibitor
Thiourea derivatives having benzimidazole 1–17 have been synthesized, characterized by 1
H NMR, 13 C NMR and EI-MS and evaluated for α-glucosidase inhibition. Identification of …
H NMR, 13 C NMR and EI-MS and evaluated for α-glucosidase inhibition. Identification of …
Thiazole-benzamide derivatives as α-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo evaluation
M Fan, Q Feng, W Yang, Z Peng, G Wang - Journal of Molecular Structure, 2023 - Elsevier
In this study, a series of thiazole-benzamide derivatives (6a-6o) was obtained by molecular
hybridization and screened for their inhibitory study towards the α-glucosidase activity. The …
hybridization and screened for their inhibitory study towards the α-glucosidase activity. The …
Synthesis of thiobarbituric acid derivatives: in vitro α-glucosidase inhibition and molecular docking studies
Synthesis, structure, and evaluation of in vitro α-glucosidase enzyme inhibition of a new
class of diethylammonium salts of aryl substituted thiobarbituric acid is described. This …
class of diethylammonium salts of aryl substituted thiobarbituric acid is described. This …
Synthesis and characterisation of thiobarbituric acid enamine derivatives, and evaluation of their α-glucosidase inhibitory and anti-glycation activity
A new series of thiobarbituric (thiopyrimidine trione) enamine derivatives and its analogues
barbituric acid derivatives was synthesised, characterised, and screen for in vitro evaluation …
barbituric acid derivatives was synthesised, characterised, and screen for in vitro evaluation …
Synthesis, biological evaluation, and molecular docking study of chromen‐linked hydrazine carbothioamides as potent α‐glucosidase inhibitors
Inhibiting α‐glucosidase is a reliable method for reducing blood sugar levels in diabetic
individuals. Several novel chromen‐linked hydrazine carbothioamide (3a–r) were designed …
individuals. Several novel chromen‐linked hydrazine carbothioamide (3a–r) were designed …
Synthesis and α-glucosidase inhibition activity of dihydroxy pyrrolidines
S Kasturi, S Surarapu, S Uppalanchi… - Bioorganic & Medicinal …, 2017 - Elsevier
A new series of Deacetylsarmentamide A and B derivatives, amides and sulfonamides of 3,
4-dihydroxypyrrolidines as α-glucosidase inhibitors were designed and synthesized. The …
4-dihydroxypyrrolidines as α-glucosidase inhibitors were designed and synthesized. The …
[HTML][HTML] Synthesis, Computational Study, and In Vitro α-Glucosidase Inhibitory Action of Thiourea Derivatives Based on 3-Aminopyridin-2(1H)-Ones
Z Shulgau, I Palamarchuk, S Sergazy, A Urazbayeva… - Molecules, 2024 - mdpi.com
Reactions with allyl-, acetyl-, and phenylisothiocyanate have been studied on the basis of 3-
amino-4, 6-dimethylpyridine-2 (1 H)-one, 3-amino-4-phenylpyridine-2-one, and 3-amino-4 …
amino-4, 6-dimethylpyridine-2 (1 H)-one, 3-amino-4-phenylpyridine-2-one, and 3-amino-4 …
Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3, 5-dicarbonitriles as novel α-glucosidase inhibitors
Inhibition of α-glucosidase enzyme is of prime importance for the treatment of diabetes
mellitus (DM). Apart of many organic scaffolds, pyridine based compounds have previously …
mellitus (DM). Apart of many organic scaffolds, pyridine based compounds have previously …
Synthesis, in vitro α-glucosidase, α-amylase inhibitory potential and molecular docking study of thiadiazole-sulfonamide hybrid analogues
We have synthesized fourteen thiadiazole-sulfonamide hybrid analogues (1–14),
characterized throygh different technequies ie, NMR, HR-EIMS, and screened against α …
characterized throygh different technequies ie, NMR, HR-EIMS, and screened against α …
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