Rationale In psychopharmacology, researchers have been interested in the hypnotic effects
of terrestrial plant polyphenols and their synthetic derivatives. Phlorotannins, a marine plant …

We had previously demonstrated that phlorotannins, which are marine polyphenols,
enhance sleep in mice via the GABAA-benzodiazepine (BZD) receptor. Among the …

In our previous studies, we have demonstrated that marine polyphenol phlorotannins
promote sleep through the benzodiazepine site of the gamma-aminobutyric acid type A …

Insomnia is a common sleep disorder. Natural sleep aids are gaining worldwide popularity
as alternatives to prescription drugs for improving sleep. Recently, numerous studies have …

In our previous studies, a standardized phlorotannin (brown seaweed polyphenol)
supplement (PS) exhibited sleep-promoting effects via type A γ-aminobutyric acid …

Sleep is vital for maintaining health and well-being; however, insomnia is currently a
widespread health complaint. According to a report from the National Sleep Foundation in …

The primary objective was to investigate whether seaweeds have hypnotic activity. Methanol
extracts of 30 seaweeds were screened for their binding activity at the GABA type A …

The aim of this study is to investigate the sleep-promoting effect of a water extract of the
Polygonatum sibiricum rhizome (PSE) in rodent models. PSE contained oleamide (0.10 …

Ethnopharmacological relevance Nelumbo nucifera are used in folk medicine for anti-
depressant, anti-convulsant, neuroprotective, and many other purposes. Aim of the study …

It has been known that RA, one of major constituents of Perilla frutescens which has been
used as a traditional folk remedy for sedation in oriental countries, shows the anxiolytic-like …