Tau aggregation is a common feature of neurodegenerative diseases such as Alzheimer's
disease, and hyperphosphorylation of tau has been implicated as a fundamental pathogenic …

Alzheimer's disease is a major cause of dementia for which treatments remain
unsatisfactory. Cyclin-dependent kinase 5 (CDK5) is a relevant kinase that has been …

Aggregation of highly phosphorylated tau into aggregated forms such as filaments and
neurofibrillary tangles is one of the defining pathological hallmarks of Alzheimer's disease …

Neurofibrillary tangles, one of the pathologic hallmarks of Alzheimer's disease (AD), are
composed of abnormally polymerized tau protein. The hyperphosphorylation of tau alters its …

Abnormally hyperphosphorylated tau is often caused by tau kinases, such as GSK3β and
Cdk5. Such occurrence leads to neurofibrillary tangle formation and neuronal degeneration …

Hyperphosphorylation of the microtubule-associated protein tau is a characteristic feature of
neurodegenerative tauopathies including Alzheimer disease. Over-activation of proline …

In healthy neurons, tau proteins regulate microtubule function in the axon. In the brains of
individuals with Alzheimer's disease, tau is hyperphosphorylated and aggregated into …

Hyperphosphorylated tau is a major component of neurofibrillary tangles, one of the
hallmarks of Alzheimer's disease. CDK5 is a kinase that phosphorylates the tau protein, and …

Neurofibrillary tangles (NFTs) are found in a wide range of neurodegenerative disorders,
including Alzheimer's disease. The major component of NFTs is aberrantly …

The relationship between amyloid plaques and neurofibrillary tangles, the two pathologic
hallmarks of Alzheimer's disease (AD), is an unknown and controversial subject. However …