Synthesis and evaluation of cytotoxic effects of amino-ester derivatives of natural α, β-amyrin mixture

MM Victor, JM David, MAS Santos… - Journal of the Brazilian …, 2017 - SciELO Brasil
Natural α, β-amyrins were isolated from endemic Brazilian Esenbeckia grandiflora Mart., and
eight synthetic derivatives were obtained by esterification reactions with bromo acetate …

[HTML][HTML] Amyrin esters induce cell death by apoptosis in HL-60 leukemia cells

FWA Barros, PN Bandeira, DJB Lima, AS Meira… - Bioorganic & medicinal …, 2011 - Elsevier
Four derivatives of an α, β-amyrin mixture were synthesized by acylation with appropriate
anhydrides. The structures of the compounds were confirmed by means of IR and 1H and …

The pentacyclic triterpenes α, β-amyrins: A review of sources and biological activities

L Hernández-Vázquez… - Chapter 23 in: Rao …, 2012 - diposit.ub.edu
Pentacyclic triterpenes are ubiquitously distributed throughout the plant kingdom, in a free
form as aglycones or in combined forms, and have long been known to have a number of …

Acute toxicity study of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum (Aubl.) Marchand.

G Frota Aragão, A Oliveira Nogueira… - Acta Scientiarum …, 2023 - search.ebscohost.com
The isomeric mixture of alpha and beta amyrin (AMY), present in the resin of Protium
heptaphyllum, is popularly used as anti-inflammatory and anti-ulcer. The literature has been …

Physicochemical characterization and biological activities of the triterpenic mixture α, β-amyrenone

RGS Ferreira, WF Silva Junior, VF Veiga Junior… - Molecules, 2017 - mdpi.com
α-Amyrenone and β-amyrenone are triterpenoid isomers that occur naturally in very low
concentrations in several oleoresins from Brazilian Amazon species of Protium …

Quantification of α‐and β‐amyrin in rat plasma by gas chromatography–mass spectrometry: application to preclinical pharmacokinetic study

J Ching, HS Lin, CH Tan, HL Koh - Journal of mass …, 2011 - Wiley Online Library
Abstract α‐and β‐Amyrins are naturally occurring triterpenes with a wide range of biological
activities. In this study, a reliable GC‐MS method was developed and validated for the …

Amyrisins A–C, O-Prenylated Flavonoids from Amyris madrensis

J Peng, RM Hartley, GA Fest… - Journal of Natural …, 2012 - ACS Publications
Three new O-prenylated flavonoids, amyrisins A–C (1–3), were isolated from the leaves and
twigs of Amyris madrensis, along with the known compound polygamain (4). The structures …

Development, Physicochemical Characterization and In Vitro Anti-Inflammatory Activity of Solid Dispersions of α,β Amyrin Isolated from Protium Oilresin

WF da Silva Júnior, JGO Pinheiro, DLB De Menezes… - Molecules, 2017 - mdpi.com
α, β Amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has shown a variety of
pharmacological properties, including anti-inflammatory effect. ABAM is isolated from …

[HTML][HTML] Synthetic derivatives of the α-and β-amyrin triterpenes and their antinociceptive properties

C Soldi, MG Pizzolatti, AP Luiz, R Marcon… - Bioorganic & medicinal …, 2008 - Elsevier
Fifteen different derivatives of an α-and β-amyrin mixture were synthesized by acylation with
appropriate anhydride or acid chlorides and oxidation in the presence of tert-butyl chromate …

Design and synthesis of triazolyl-napthyl derivative of β-amyrin and its in vitro anti-cancer and apoptotic activities in human nasopharyngeal carcinoma (HK-1) cell line

Z Li, HZ Ge, YG Xie, S Li - ||| Bangladesh Journal of Pharmacology …, 2016 - bdpsjournal.org
The purpose of this research work was to design and synthesize triazolylnapthyl derivative
of β-amyrin (TNB) using click chemistry approach. The cytotoxic activity of TNB was …