PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP
A Kuburas, BN Mason, B Hing, AS Wattiez… - Journal of …, 2021 - Soc Neuroscience
The neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …
CGRP and migraine: could PACAP play a role too?
Migraine is a debilitating neurological disorder that affects about 12% of the population. In
the past decade, the role of the neuropeptide calcitonin gene-related peptide (CGRP) in …
the past decade, the role of the neuropeptide calcitonin gene-related peptide (CGRP) in …
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
[HTML][HTML] Role of PACAP in migraine: An alternative to CGRP?
Migraine is a widespread and debilitating neurological condition affecting more than a
billion people worldwide. Thus, more effective migraine therapies are highly needed. In the …
billion people worldwide. Thus, more effective migraine therapies are highly needed. In the …
Induction of migraine-like photophobic behavior in mice by both peripheral and central CGRP mechanisms
BN Mason, EA Kaiser, A Kuburas… - Journal of …, 2017 - Soc Neuroscience
The neuropeptide calcitonin gene-related peptide (CGRP) is a key player in migraine.
Although migraine can be treated using CGRP antagonists that act peripherally, the relevant …
Although migraine can be treated using CGRP antagonists that act peripherally, the relevant …
The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?
C Ernstsen, SL Christensen, RH Rasmussen… - Brain, 2022 - academic.oup.com
Calcitonin gene-related peptide (CGRP)-antagonizing drugs represent a major advance in
migraine treatment. However, up to 50% of patients do not benefit from monoclonal …
migraine treatment. However, up to 50% of patients do not benefit from monoclonal …
Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine
A Recober, A Kuburas, Z Zhang… - Journal of …, 2009 - Soc Neuroscience
Migraine is a chronic neurological disorder characterized by recurrent episodes of severe
unilateral throbbing head pain and associated symptoms, such as photophobia. Our current …
unilateral throbbing head pain and associated symptoms, such as photophobia. Our current …
Calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide in migraine treatment
R Dominguez-Moreno, TP Do… - Current Opinion in …, 2022 - journals.lww.com
Calcitonin gene-related peptide and pituitary adenylate cycl... : Current Opinion in
Endocrinology, Diabetes and Obesity Calcitonin gene-related peptide and pituitary …
Endocrinology, Diabetes and Obesity Calcitonin gene-related peptide and pituitary …
Calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in migraine pathogenesis
Migraine is a prevalent and debilitating neurologic disorder. Advancements in
understanding the underlying pathophysiological mechanisms are spearheading the effort …
understanding the underlying pathophysiological mechanisms are spearheading the effort …
Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT1B/D agonist
EA Kaiser, A Kuburas, A Recober… - Journal of …, 2012 - Soc Neuroscience
The neuropeptide calcitonin gene-related peptide (CGRP) plays a critical role in the
pathophysiology of migraine. We have focused on the role of CGRP in photophobia, which …
pathophysiology of migraine. We have focused on the role of CGRP in photophobia, which …