Tumor hypoxia has been established as an independent prognostic factor associated with
poor patient survival and resistance to conventional therapies. Emerging evidence suggests …

Tumor sensitivity to radiation therapy has been known to be dependent on O 2
concentrations. However, radiosensitivity of naturally occurring hypoxic tumor cells remains …

Hypoxia or oxygen deficiency is a salient feature of solid tumors. Hypoxic tumors are often
resistant to conventional cancer therapies, and tumor hypoxia correlates with advanced …

Background Tumor hypoxia is an independent prognostic factor associated with poor patient
survival. Emerging evidence suggests that hypoxia can potentially maintain or enhance the …

The role of tumor interaction with stromal components during carcinogenesis is crucial for
the design of efficient cancer treatment approaches. It is widely admitted that tumor hypoxic …

Solid tumors often contain regions with insufficient oxygen delivery, a condition called
hypoxia. Tumor hypoxia is an independent prognostic factor significantly correlated with …

Tumors often start out as a benign growth, but gradually progress toward the malignant
stage over a relatively long period of time. Tumor progression results from accumulated …

Hypoxia occurs in 90% of solid tumors due to inefficient vasculature and has been
demonstrated to promote a more aggressive phenotype, correlating with worse patient …

Tumors are often viewed as unique entities with specific behaviors. However, tumors are a
mixture of differentially evolved subpopulations of cells in constant Darwinian evolution …

Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …