Familial combined hyperlipidemia is a polygenic trait

PK Gill, RA Hegele - Current opinion in lipidology, 2022 - journals.lww.com
Recent progress in genomics has shown that most if not all of the genetic susceptibility to
FCH is polygenic in nature. Future research should include larger cohort studies, with wider …

Unraveling the complex genetics of familial combined hyperlipidemia

E Suviolahti, HE Lilja, P Pajukanta - Annals of medicine, 2006 - Taylor & Francis
Familial combined hyperlipidemia (FCHL) constitutes a substantial risk factor for
atherosclerosis since it is observed in about 20% of coronary heart disease (CHD) patients …

Genetics of familial combined hyperlipidemia

P Pajukanta, KVK Porkka - Current Atherosclerosis Reports, 1999 - Springer
Complex disorders are caused by several environmental factors that interact with multiple
genes. These diseases are common at the population level and constitute a major health …

Genetics of familial combined hyperlipidemia (FCHL) disorder: an update

E Taghizadeh, N Farahani, R Mardani, F Taheri… - Biochemical …, 2022 - Springer
Familial combined hyperlipidemia (FCHL) is one of the most common familial lipoprotein
disorders of the lipoproteins, with a prevalence of 0.5% to 2% in different populations. About …

Familial combined hyperlipidemia: from molecular insights to tailored therapy

MMJ van Greevenbroek, AFH Stalenhoef… - Current opinion in …, 2014 - journals.lww.com
Ongoing basic research provides a steady growth in our knowledge on the genes that are
involved in FCHL as well as their metabolic function (s). This field of research may be …

Genetic dissection of familial combined hyperlipidemia

PMH Eurlings, CJH van der Kallen, JMW Geurts… - Molecular genetics and …, 2001 - Elsevier
Familial combined hyperlipidemia (FCHL) is the most common genetic hyperlipidemia in
man. FCHL is characterized by familial clustering of hyperlipidemia and clinical …

Molecular mechanisms, prevalence, and molecular methods for familial combined hyperlipidemia disease: A review

E Taghizadeh, R Mardani, D Rostami… - Journal of cellular …, 2019 - Wiley Online Library
Familial combined hyperlipidemia (FCHL) is the most common genetic dyslipidemia
disorder which is accompanied by increasing of triglyceride and cholesterol. This disorder is …

Polygenic architecture and cardiovascular risk of familial combined hyperlipidemia

M Trinder, D Vikulova, S Pimstone, GBJ Mancini… - Atherosclerosis, 2022 - Elsevier
Background and aims Familial combined hyperlipidemia (FCHL) is one of the most common
inherited lipid phenotypes, characterized by elevated plasma concentrations of …

Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and …

P Pajukanta, JD Terwilliger, M Perola… - The American Journal of …, 1999 - cell.com
Familial combined hyperlipidemia (FCHL) is a common dyslipidemia predisposing to
premature coronary heart disease (CHD). The disease is characterized by increased levels …

Genetics of familial combined hyperlipidemia and risk of coronary heart disease

CC Shoulders, EL Jones… - Human molecular …, 2004 - academic.oup.com
Coronary heart disease is the leading cause of death in developed countries. This alarming
statistic is partly attributable to lifestyle, and partly due to the genetic factors that make …