Inhibition of antiviral innate immunity by birnavirus VP3 protein via blockage of viral double-stranded RNA binding to the host cytoplasmic RNA detector MDA5.
YCJ Ye ChengJin, JL Jia Lu, SYT Sun YanTing… - 2014 - cabidigitallibrary.org
Abstract Chicken MDA5 (chMDA5), the sole known pattern recognition receptor for
cytoplasmic viral RNA in chickens, initiates type I interferon (IFN) production. Infectious …
cytoplasmic viral RNA in chickens, initiates type I interferon (IFN) production. Infectious …
Inhibition of antiviral innate immunity by birnavirus VP3 protein via blockage of viral double-stranded RNA binding to the host cytoplasmic RNA detector MDA5
ABSTRACT Chicken MDA5 (chMDA5), the sole known pattern recognition receptor for
cytoplasmic viral RNA in chickens, initiates type I interferon (IFN) production. Infectious …
cytoplasmic viral RNA in chickens, initiates type I interferon (IFN) production. Infectious …
Bovine viral diarrhea virus NS4B protein interacts with 2CARD of MDA5 domain and negatively regulates the RLR-mediated IFN-β production
Y Shan, Z Tong, M Jinzhu, L Yu, Z Zecai, W Chenhua… - Virus Research, 2021 - Elsevier
Bovine viral diarrhea virus (BVDV) is an important member of the family Flaviviridae and
often causes immunosuppression. Previous studies have suggested that BVDV envelope …
often causes immunosuppression. Previous studies have suggested that BVDV envelope …
Chicken melanoma differentiation-associated gene 5 (MDA5) recognizes infectious bursal disease virus infection and triggers MDA5-related innate immunity
CC Lee, CC Wu, TL Lin - Archives of virology, 2014 - Springer
The objective of the present study was to determine if chicken melanoma differentiation-
associated gene 5 (MDA5) senses infectious bursal disease virus (IBDV) infection to initiate …
associated gene 5 (MDA5) senses infectious bursal disease virus (IBDV) infection to initiate …
Role of chicken melanoma differentiation-associated gene 5 in induction and activation of innate and adaptive immune responses to infectious bursal disease virus in …
CC Lee, CC Wu, TL Lin - Archives of virology, 2015 - Springer
The objective of the present study was to determine if chicken melanoma-differentiation-
associated gene 5 (MDA5) senses infectious bursal disease virus infection to induce innate …
associated gene 5 (MDA5) senses infectious bursal disease virus infection to induce innate …
gga-miR-142-5p attenuates IRF7 signaling and promotes replication of IBDV by directly targeting the chMDA5′ s 3′ untranslated region
W Ouyang, J Qian, Q Pan, J Wang, X Xia, X Wang… - Veterinary …, 2018 - Elsevier
Chicken melanoma differentiation-associated gene 5 (chMDA5) is a key pattern recognition
receptor (PRR) that recognizes RNA viral infections and initiates an antiviral innate immune …
receptor (PRR) that recognizes RNA viral infections and initiates an antiviral innate immune …
Interaction between chicken TRIM25 and MDA5 and their role in mediated antiviral activity against IBDV infection
E Diaz-Beneitez, LL Cubas-Gaona… - Frontiers in …, 2022 - frontiersin.org
Infectious Bursal Disease Virus (IBDV) is the causative agent of an immunosuppressive
disease that affects domestic chickens (Gallus gallus) severely affecting poultry industry …
disease that affects domestic chickens (Gallus gallus) severely affecting poultry industry …
Transcriptomic analysis of the chicken MDA5 response genes
S Yu, H Mao, M Jin, X Lin - Genes, 2020 - mdpi.com
RIG-I and MDA5 are two key pattern recognition receptors that sense RNA virus invasion,
but RIG-I is absent in chickens. Although chickens have intact MDA5, the genes downstream …
but RIG-I is absent in chickens. Although chickens have intact MDA5, the genes downstream …
Role of chicken melanoma differentiation-associated gene 5 in induction and activation of innate and adaptive immune responses to infectious bursal disease virus in …
LCC Lee ChihChun, WCC Wu ChingChing… - 2015 - cabidigitallibrary.org
The objective of the present study was to determine if chicken melanoma-differentiation-
associated gene 5 (MDA5) senses infectious bursal disease virus infection to induce innate …
associated gene 5 (MDA5) senses infectious bursal disease virus infection to induce innate …
Chicken MDA5 senses short double-stranded RNA with implications for antiviral response against avian influenza viruses in chicken
T Hayashi, C Watanabe, Y Suzuki, T Tanikawa… - Journal of innate …, 2014 - karger.com
Mammalian melanoma differentiation-associated gene-5 (MDA5) and retinoic acid-inducible
gene-I (RIG-I) selectively sense double-stranded RNA (dsRNA) according to length, as well …
gene-I (RIG-I) selectively sense double-stranded RNA (dsRNA) according to length, as well …