The diverse roles of DNA methylation in mammalian development and disease

MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Dynamics and context-dependent roles of DNA methylation

C Ambrosi, M Manzo, T Baubec - Journal of molecular biology, 2017 - Elsevier
DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

Emerging concept in DNA methylation: role of transcription factors in shaping DNA methylation patterns

C Marchal, B Miotto - Journal of cellular physiology, 2015 - Wiley Online Library
DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

DNA methylation and human disease

KD Robertson - Nature Reviews Genetics, 2005 - nature.com
DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

DNA methylation dynamics in health and disease

Y Bergman, H Cedar - Nature structural & molecular biology, 2013 - nature.com
DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …

Non-canonical functions of the DNA methylome in gene regulation

JP Reddington, S Pennings, RR Meehan - Biochemical Journal, 2013 - portlandpress.com
Methylation of the cytosine base in DNA, DNA methylation, is an essential epigenetic mark
in mammals that contributes to the regulation of transcription. Several advances have been …

DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

[HTML][HTML] The cell biology of DNA methylation in mammals

E Prokhortchouk, PA Defossez - … et Biophysica Acta (BBA)-Molecular Cell …, 2008 - Elsevier
In this review, we will provide a brief reminder of epigenetic phenomena in general, and
DNA methylation in particular. We will then underline the characteristics of the in vivo …

Expression of various genes is controlled by DNA methylation during mammalian development

M Ehrlich - Journal of cellular biochemistry, 2003 - Wiley Online Library
Despite thousands of articles about 5-methylcytosine (m5C) residues in vertebrate DNA,
there is still controversy concerning the role of genomic m5C in normal vertebrate …

Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer

M Kulis, AC Queirós, R Beekman… - Biochimica et Biophysica …, 2013 - Elsevier
Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …