Background The NLRP3 inflammasome is a vital player in the emergence of inflammation.
The priming and activation of the NLRP3 inflammasome is a major trigger for inflammation …

Cannabidiol (CBD), a phytocannabinoid, has been reported to have anti-inflammatory
effects associated with NLRP3 inflammasome activation, but its mechanism of anti …

Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect
microbial materials, sterile inflammatory insults, and certain host-derived elements …

Cannabinoids, mainly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), are the most
studied group of compounds obtained from Cannabis sativa because of their several …

Inflammation is a natural response of the body to signals of tissue damage or infection
caused by pathogens. However, when it becomes imbalanced, it can lead to various …

Many psychiatric patients do not respond to conventional therapy. There is a vast effort to
investigate possible mechanisms involved in treatment resistance, trying to provide better …

Neuroinflammation stands as a critical player in the pathogenesis of diverse neurological
disorders, with microglial cells playing a central role in orchestrating the inflammatory …

The aberrant activation of NLRP3 inflammasome contributes to pathogenesis of multiple
inflammation-driven human diseases. However, the medications targeting NLRP3 …

Many patients with depressive disorder do not respond to conventional antidepressant
treatment. There is an ongoing interest in investigating potential mechanisms of treatment …

Inflammasomes are involved in diverse inflammatory diseases, so the activation of
inflammasomes needs to be tightly controlled to prevent excessive inflammation. However …