Mitochondria are essential for neuronal survival and function. Proper degradation of aged
and damaged mitochondria through mitophagy is a key cellular pathway for mitochondrial …

To minimize oxidative damage to the cell, malfunctioning mitochondria need to be removed
by mitophagy. In neuronal axons, mitochondrial damage may occur in distal regions, far from …

Selective autophagy of mitochondria, known as mitophagy, is an important mitochondrial
quality control mechanism that eliminates damaged mitochondria. Mitophagy also mediates …

Parkinson's disease (PD) is characterized by massive degeneration of dopaminergic
neurons in the substantia nigra. Whereas the majority of PD cases are sporadic, about 5 …

Disruption of the dynamic properties of mitochondria (fission, fusion, transport, degradation,
and biogenesis) has been implicated in the pathogenesis of neurodegenerative disorders …

Macroautophagy is a cellular process by which cytosolic components and organelles are
degraded in double-membrane bound structures upon fusion with lysosomes. A pathway for …

Mitochondria are the powerhouses for the cell, consuming oxygen to generate sufficient
energy for the maintenance of normal cellular processes. However, a deleterious …

Neurons are highly specialised cells with a large bioenergetic demand, and so require a
healthy mitochondrial network to function effectively. This network is compromised in many …

Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and
PARK2/Parkin mutations cause autosomal recessive forms of Parkinson's disease. Upon a …

In neurons, the normal distribution and selective removal of mitochondria are considered
essential for maintaining the functions of the large asymmetric cell and its diverse …