HIV‐1 evolved from SIV during cross‐species transmission events, though viral genetic
changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV‐1 …

Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV‐1 are not well
understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV‐1 …

HIV‐1 evolved from its progenitor SIV strains, but details are lacking on its adaptation to the
human host. We followed the evolution of SIVcpz in humanized mice to mimic cross‐species …

The genetic evolution of HIV-1 from its progenitor virus SIV following cross-species
transmission is not well understood. Here we simulated the SIVcpz initial transmission to …

HIV‐1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for
assessing viral evolution via measuring viral loads, CD4+ T cell decline, and analyzing …

How SIV progenitors evolved into deadly HIV‐1 and HIV‐2 following initial cross‐species
transmission still remains a mystery. Here, we used humanized mice as a human surrogate …

Cross-species transmission (CST) has led to many devastating epidemics, but is still a
poorly understood phenomenon. HIV-1 and HIV-2 (human immunodeficiency virus 1 and 2) …

The origins of human immunodeficiency virus type 1 (HIV-1) have been widely accepted to
be the consequences of simian immunodeficiency viruses from wild chimpanzees (SIVcpz) …

Pandemic HIV-1, a human lentivirus, is the result of zoonotic transmission of SIV from
chimpanzees (SIVcpz). How SIVcpz established spread in humans after spillover is an …

All four subspecies of chimpanzees are endangered. Differing in their demographic histories
and geographical ranges within sub-Saharan Africa, they have likely adapted to different …