Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …

There is considerable interest in the involvement of cyclooxygenase-2 (COX-2) in colon
carcinogenesis and its progression, because nonsteroidal anti-inflammatory drugs (NSAIDs) …

Background Cyclo-oxygenase inhibition for the treatment of colorectal neoplasia has been
studied with renewed interest since the discovery of cyclo-oxygenase (Cox) 2 and the …

Background Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of
prostaglandins. It exists in two isoforms: COX-1 which is constitutively expressed and COX-2 …

Cyclooxygenase-2 (COX-2) is an inducible enzyme which triggers the biosynthesis of
prostaglandins. COX-2 is activated in response to inflammatory stimuli and is one of the …

Use of nonsteroidal anti‐inflammatory drugs such as aspirin, which are known to inhibit
cyclooxygenase activity, reduces the relative risk of colorectal cancer in humans by 40–50 …

Inhibitors of the inducible cyclooxygenase (COX‐2) have emerged as a promising new class
of drugs that may be useful for the prevention of colorectal cancer. Experimental evidence to …

Numerous investigations have shown that COX-2 is a participant in the pathway of colon
carcinogenesis, especially when mutation of the APC tumor suppressor is the initiating …

Non‐steroidal anti‐inflammatory drugs are chemopreventive for colorectal cancer. This
effect is due in part to their ability to inhibit the inducible isoform of cyclooxygenase (COX‐2) …