The MYC oncogene is overexpressed in hepatocellular carcinoma (HCC) and has been
associated with widespread microRNA (miRNA) repression; however, the underlying …

c‐Myc is a well‐known oncogene frequently up‐regulated in different malignancies,
whereas liver‐specific microRNA (miR)‐122, a bona fide tumor suppressor, is down …

Abstract c‐Myc (Myc) plays an important role in normal liver development and
tumorigenesis. We show here that Myc is pathologically activated in and essential for …

Background Recent profile studies of microRNA (miRNA) expression have documented a
deregulation of miRNA (miR-124) in hepatocellular carcinoma (HCC). Objective To …

The transcription factor c-Myc is a key driver for hepatocellular carcinomas (HCCs), while the
polycombrepressive complex 2 (PRC2) subunit EZH2 is an essential biomarker of HCC. c …

Primary hepatic tumors mainly include hepatocellular carcinoma (HCC), which is one of the
most frequent causes of cancer‐related deaths worldwide. Thus far, HCC prognosis has …

Cumulative evidence suggests that microRNAs (miRNAs) promote gene expression in
cancers. However, the pathophysiologic relevance of miRNA-mediated RNA activation in …

Background & Aims Hepatocellular carcinoma (HCC) is a cancer with multiple aetiologies
and widespread prevalence. Largely refractory to current treatments, HCC is the fourth …

Deregulation of microRNAs (miRNAs) and c-Myc (Myc) contributes to hepatocellular
carcinoma (HCC) progression, but how miRNAs and Myc regulate each other in …

By comparing the expression profiles of miRNAs in different subtypes of HCC, we identified
miR-424 as a HCC related miRNA. We found that the expression of miR-424 was …