Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology

V Krizhanovsky, W Xue, L Zender… - Cold Spring Harbor …, 2008 - symposium.cshlp.org
Cellular senescence is characterized by an irreversible cell cycle arrest that, when bypassed
by mutation, contributes to cellular immortalization. Activated oncogenes induce a …

The ageing epigenome and its rejuvenation

W Zhang, J Qu, GH Liu, JCI Belmonte - Nature reviews Molecular cell …, 2020 - nature.com
Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

Interaction between epigenetic and metabolism in aging stem cells

A Brunet, TA Rando - Current Opinion in Cell Biology, 2017 - Elsevier
Aging is accompanied by a decline in tissue function, regeneration, and repair. A large part
of this decline is caused by the deterioration of tissue stem cell function. Understanding the …

Cellular senescence in aging and age-related disease: from mechanisms to therapy

BG Childs, M Durik, DJ Baker, JM Van Deursen - Nature medicine, 2015 - nature.com
Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Cellular senescence: Molecular mechanisms and pathogenicity

W Wei, S Ji - Journal of cellular physiology, 2018 - Wiley Online Library
Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

New horizons: novel approaches to enhance healthspan through targeting cellular senescence and related aging mechanisms

T Tchkonia, AK Palmer… - The Journal of Clinical …, 2021 - academic.oup.com
The elderly population is increasing faster than other segments of the population throughout
the world. Age is the leading predictor for most chronic diseases and disorders …

Anti-aging strategies based on cellular reprogramming

A Ocampo, P Reddy, JCI Belmonte - Trends in molecular medicine, 2016 - cell.com
Aging can be defined as the progressive decline in the ability of a cell or organism to resist
stress and disease. Recent advances in cellular reprogramming technologies have enabled …

[HTML][HTML] Principles of the molecular and cellular mechanisms of aging

PFL da Silva, B Schumacher - Journal of Investigative Dermatology, 2021 - Elsevier
Aging can be defined as a state of progressive functional decline accompanied by an
increase in mortality. Time-dependent accumulation of cellular damage, namely lesions and …

Senescence under appraisal: hopes and challenges revisited

CSA Davan-Wetton, E Pessolano, M Perretti… - Cellular and Molecular …, 2021 - Springer
In recent years, cellular senescence has become the focus of attention in multiple areas of
biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by …

[HTML][HTML] The hallmarks of aging

C López-Otín, MA Blasco, L Partridge, M Serrano… - Cell, 2013 - cell.com
Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …