Cellular senescence is characterized by an irreversible cell cycle arrest that, when bypassed
by mutation, contributes to cellular immortalization. Activated oncogenes induce a …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

The elderly population is increasing faster than other segments of the population throughout
the world. Age is the leading predictor for most chronic diseases and disorders …

Aging is accompanied by a decline in tissue function, regeneration, and repair. A large part
of this decline is caused by the deterioration of tissue stem cell function. Understanding the …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Aging can be defined as the progressive decline in the ability of a cell or organism to resist
stress and disease. Recent advances in cellular reprogramming technologies have enabled …

In recent years, cellular senescence has become the focus of attention in multiple areas of
biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by …

Aging can be defined as a state of progressive functional decline accompanied by an
increase in mortality. Time-dependent accumulation of cellular damage, namely lesions and …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …