The underlying cause of aging remains one of the central mysteries of biology. Recent
studies in several different systems suggest that not only may the rate of aging be modified …

Aging is a major risk factor for numerous human pathologies, including cardiovascular,
metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies …

The term cellular senescence was used in 1961 for the first time by Hayflick and Moorhead
[1], to define the mechanism determining the irreversible loss of the proliferative activity of …

Cellular senescence is a complex and multistep biological process which cells can undergo
in response to different stresses. Referring to a highly stable cell cycle arrest, cellular …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Adult stem cells exist in most mammalian organs and tissues and are indispensable for
normal tissue homeostasis and repair. In most tissues, there is an age-related decline in …

Cellular senescence, a permanent state of cell cycle arrest accompanied by a complex
phenotype, is an essential mechanism that limits tumorigenesis and tissue damage. In …

Organismal aging and longevity are influenced by many complex interacting factors.
Epigenetics has recently emerged as another possible determinant of aging. Here, we …

Cellular senescence is a proliferation arrest that is typically irreversible and caused by
various cellular stresses, including excess rounds of cell division and cancer-causing …

Aging is associated with a wide range of human disorders, including cancer, diabetes,
cardiovascular, and neurodegenerative diseases. Long thought to be an inexorable road …