Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

The aging of the world's population has intensified interest in understanding the aging
process and devising strategies and interventions to prolong a healthy life span. Cellular …

Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-
suppressive mechanism. However, due to the associated secretory phenotype senescence …

Aging is the result of a gradual functional decline at the cellular, and ultimately, organismal
level, resulting in an increased risk of developing a variety of chronic illnesses, such as …

Stem cell decline is an important cellular driver of aging-associated pathophysiology in
multiple tissues. Epigenetic regulation is central to establishing and maintaining stem cell …

Cellular senescence, once thought an artifact of in vitro culture or passive outcome of aging,
has emerged as fundamental to tissue development and function. The senescence …

Mammalian aging can be delayed with genetic, dietary and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

One of the original hypotheses of organismal longevity posits that aging is the natural result
of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into …

Cellular senescence is a state of stable cell cycle arrest arising in response to DNA and
mitochondrial damages. Senescent cells undergo morphological, structural and functional …