Effects of vitamin E on cytotoxicity of amiodarone and N-desethylamiodarone in isolated hamster lung cells

MW Bolt, WJ Racz, JF Brien, TE Massey - Toxicology, 2001 - Elsevier
Amiodarone (AM) is a potent and efficacious antidysrhythmic agent that can cause
potentially life-threatening pulmonary fibrosis. Vitamin E has been demonstrated to …

Effects of dietary vitamin E supplementation on pulmonary morphology and collagen deposition in amiodarone-and vehicle-treated hamsters

JW Card, RG Leeder, WJ Racz, JF Brien, TM Bray… - Toxicology, 1999 - Elsevier
Amiodarone (AM) is a potent antidysrhythmic agent that is limited in clinical use by its
adverse effects, including potentially life-threatening AM-induced pulmonary toxicity (AIPT) …

[HTML][HTML] Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro

R Bargout, A Jankov, E Dincer… - … of Physiology-Lung …, 2000 - journals.physiology.org
The antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (Des) are
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …

Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells

JE Mulder, JF Brien, WJ Racz, T Takahashi… - … of Pharmacology and …, 2011 - ASPET
Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-
threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may …

Comparison of the in vivo pulmonary toxicity of amiodarone and des-oxo-amiodarone in the hamster

E Rafeiro, RG Leeder, JF Brien, GW Kabalka… - Toxicology and applied …, 1994 - Elsevier
Amiodarone (AM) is an effective antidysrhythmic agent, the use of which is limited because
of the drug′ s potential for causing life-threatening pulmonary fibrosis. Oxidative stress …

Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity

MW Bolt, JW Card, WJ Racz, JF Brien… - Journal of Pharmacology …, 2001 - ASPET
Amiodarone (AM), a potent antidysrhythmic agent, can cause potentially life-threatening
pulmonary fibrosis. In the present investigation of mechanisms of initiation of AM lung …

Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells

FC Roth, JE Mulder, JF Brien, T Takahashi… - Chemico-biological …, 2013 - Elsevier
The potent and efficacious anti-dysrhythmic agent amiodarone (AM) can cause potentially
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is …

Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages

Y Futamura - The Journal of toxicological sciences, 1996 - jstage.jst.go.jp
This study was designed to specify the toxicity of amiodarone toward mouse pulmonary
endothelial cells in comparison with that of another cationic amphiphilic drug, ie, mianserin …

Amiodarone-induced injury of human pulmonary artery endothelial cells: protection by alpha-tocopherol.

DL Kachel, TP Moyer, WJ Martin - Journal of Pharmacology and …, 1990 - ASPET
Amiodarone is a potent antidysrhythmic drug that is associated with severe pulmonary
toxicity. The mechanism of amiodarone pulmonary toxicity is poorly understood. To …

Amiodarone-induced pulmonary toxicity in Fischer rats: release of tumor necrosis factor alpha and transforming growth factor beta by pulmonary alveolar …

PG Reinhart, CG Gairola - Journal of toxicology and environmental …, 1997 - Taylor & Francis
Amiodarone is an antiarrhythmic drug with numerous side effects, the most serious being the
development of pulmonary toxicity. We have previously reported that a single intratra cheal …