Amorphous solid dispersions of BCS class II drugs: a rational approach to solvent and polymer selection

MT Davis, DP Egan, M Kuhs, AB Albadarin… - … research and design, 2016 - Elsevier
Miniaturised solvent casting (MSC) has been developed as a method for screening the
stability of amorphous solid dispersions (ASD) of BCS class II drugs. The aim of the work …

Amorphous solid dispersions: Rational selection of a manufacturing process

T Vasconcelos, S Marques, J das Neves… - Advanced drug delivery …, 2016 - Elsevier
Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …

[HTML][HTML] Solvent influence on the phase behavior and glass transition of Amorphous Solid Dispersions

S Dohrn, C Luebbert, K Lehmkemper… - European Journal of …, 2021 - Elsevier
Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for
their successful approval for market. ASD stability does not only depend on the interplay …

Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products

P Pandi, R Bulusu, N Kommineni, W Khan… - International journal of …, 2020 - Elsevier
Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …

Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations

SK Saha, A Joshi, R Singh, K Dubey - Pharmaceutical …, 2023 - Taylor & Francis
Evolving therapeutic landscape through combinatorial chemistry and high throughput
screening have resulted in an increased number of poorly soluble drugs. Drug delivery …

Effects of the preparation process on the properties of amorphous solid dispersions

S Huang, RO Williams - Aaps Pharmscitech, 2018 - Springer
The use of amorphous solid dispersions to improve the bioavailability of active ingredients
from the BCS II and IV classifications continues to gain interest in the pharmaceutical …

[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

The role of the carrier in the formulation of pharmaceutical solid dispersions. Part II: amorphous carriers

T Van Duong, G Van den Mooter - Expert opinion on drug delivery, 2016 - Taylor & Francis
Introduction: Amorphous solid dispersions are considered as one of the most powerful
strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical …

New strategies for improving the development and performance of amorphous solid dispersions

A Haser, F Zhang - Aaps Pharmscitech, 2018 - Springer
The understanding of amorphous solid dispersions has grown significantly in the past
decade. This is evident from the number of approved commercial amorphous solid …

Evaluation on the drug–polymer mixing status in amorphous solid dispersions at the early stage formulation and process development

H Ma, DS Choi, YE Zhang, H Tian, N Shah… - Journal of …, 2013 - Springer
Drug and polymer mixing status in amorphous solid dispersions, an important aspect with
regard to the physical stability and in vivo performance of such systems, was evaluated in …