Advances in epigenetic research of adolescent idiopathic scoliosis and congenital scoliosis
D Sun, Z Ding, Y Hai, Y Cheng - Frontiers in Genetics, 2023 - frontiersin.org
Scoliosis is a three-dimensional structural deformity of the spine; more than 80% of scoliosis
has no specific pathogenesis but is understood to be closely related to genetic, hormonal …
has no specific pathogenesis but is understood to be closely related to genetic, hormonal …
Whole-genome methylation analysis reveals novel epigenetic perturbations of congenital scoliosis
Congenital scoliosis (CS) is a congenital disease caused by malformations of vertebrae.
Recent studies demonstrated that DNA modification could contribute to the pathogenesis of …
Recent studies demonstrated that DNA modification could contribute to the pathogenesis of …
Whole-genome methylation analysis of phenotype discordant monozygotic twins reveals novel epigenetic perturbation contributing to the pathogenesis of adolescent …
Background: Adolescent idiopathic scoliosis (AIS) is a complex disease affecting a large
number of teenagers, especially in female. This study reveals novel epigenetic perturbation …
number of teenagers, especially in female. This study reveals novel epigenetic perturbation …
Severity of idiopathic scoliosis is associated with differential methylation: An epigenome-wide association study of monozygotic twins with idiopathic scoliosis
PM Carry, EA Terhune, GD Trahan, LA Vanderlinden… - Genes, 2021 - mdpi.com
Epigenetic mechanisms may contribute to idiopathic scoliosis (IS). We identified 8
monozygotic twin pairs with IS, 6 discordant (Cobb angle difference> 10°) and 2 concordant …
monozygotic twin pairs with IS, 6 discordant (Cobb angle difference> 10°) and 2 concordant …
[HTML][HTML] Genetics and Pathogenesis of Scoliosis
Background Scoliosis is defined as a lateral spine curvature of at least 10° with vertebral
rotation, as seen on a posterior-anterior radiograph, often accompanied by reduced thoracic …
rotation, as seen on a posterior-anterior radiograph, often accompanied by reduced thoracic …
Abnormal TNS3 gene methylation in patients with congenital scoliosis
YT Wu, H Zhang, M Tang, C Guo, S Liu, J Li… - BMC Musculoskeletal …, 2022 - Springer
Background Congenital scoliosis (CS) is a congenital deformity of the spine resulting from
abnormal and asymmetrical development of vertebral bodies during pregnancy. However …
abnormal and asymmetrical development of vertebral bodies during pregnancy. However …
Research progress on the etiology and pathogenesis of adolescent idiopathic scoliosis
Y Peng, SR Wang, GX Qiu, JG Zhang… - Chinese medical …, 2020 - journals.lww.com
Etiology of adolescent idiopathic scoliosis (AIS), a complicated three-dimensional spinal
deformity with early-onset, receives continuous attention but remains unclear. To gain an …
deformity with early-onset, receives continuous attention but remains unclear. To gain an …
Value of DNA methylation in predicting curve progression in patients with adolescent idiopathic scoliosis
Y Meng, T Lin, S Liang, R Gao, H Jiang, W Shao… - …, 2018 - thelancet.com
Background There is considerable discordance in the curve progression of adolescent
idiopathic scoliosis (AIS) patients between monozygotic (MZ) twins, indicating that …
idiopathic scoliosis (AIS) patients between monozygotic (MZ) twins, indicating that …
Understanding genetic factors in idiopathic scoliosis, a complex disease of childhood
CA Wise, X Gao, S Shoemaker, D Gordon… - Current …, 2008 - ingentaconnect.com
Idiopathic scoliosis (AIS) is the most common pediatric spinal deformity, affecting∼ 3% of
children worldwide. AIS significantly impacts national health in the US alone, creating …
children worldwide. AIS significantly impacts national health in the US alone, creating …
High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis
Y Wu, H Zhang, M Tang, C Guo, A Deng, J Li… - Journal of Translational …, 2020 - Springer
Background The etiology of congenital scoliosis (CS) is complex and uncertain. Abnormal
DNA methylation affects the growth and development of spinal development. In this study …
DNA methylation affects the growth and development of spinal development. In this study …
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