NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique
pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting …

Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …

NLRX1 is a mitochondrial Nod-like receptor (NLR) protein whose function remains
enigmatic. Here, we observed that NLRX1 expression was glucose-regulated and blunted …

Mitochondria are known to be semi-autonomous organelles that are responsible for energy
production and cellular respiration. Mitochondria break down glucose to release energy in …

NLRX1 is the only member of the Nod-like receptor (NLR) family that is targeted to the
mitochondria, and its overexpression induces the generation of reactive oxygen species …

The role of mitochondria is emerging in regulation of innate immunity, inflammation and cell
death beyond its primary role in energy metabolism. Mitochondria act as molecular platform …

NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …

Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect
exogenous or endogenous danger signals and even the changes of their microenvironment …

NOD‐like receptors (NLRs) are a family of intracellular sensors of microbial‐or danger‐
associated molecular patterns. Here, we report the identification of NLRX1, which is a new …

Among nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), NOD-like
receptor X1 (NLRX1) is the only known NLR family member that is targeted to the …