Changes in co-receptor-use by human immunodeficiency virus type 1 (HIV-1) strains are
relatively rare in vivo. Here we describe two variants derived from the CCR5-using strain …

We studied the replication of HIV-1 macrophage-tropic CCR5-using strains (R5) in CD4+ T
cell lines to better understand the switch in co-receptor use of such strains during disease …

In human immunodeficiency virus type 1 (HIV-1) subtype B, CXCR4 coreceptor use ranges
from∼ 20% in early infection to∼ 50% in advanced disease. Coreceptor use by non …

The chemokine receptor CCR5 acts as an essential cofactor for cell entry by macrophage-
tropic human immunodeficiency virus type 1 (HIV-1) strains, whereas CXCR4 acts as an …

Coreceptor specificity of human immunodeficiency virus type 1 (HIV-1) strains is generally
defined in vitro in cell lines expressing CCR5 or CXCR4, but lymphocytes and macrophages …

Human immunodeficiency virus type 1 (HIV-1) variants that use the coreceptor CCR5 for
entry (R5; macrophage tropic) predominate in early infection, while variants that use CXCR4 …

Coreceptor utilization by HIV-1 is an important determinant of pathogenesis. However,
coreceptor selectivity is defined in vitro, while in vivo critical pathogenic events occur in …

Coreceptor usage by Envs from diverse primary human immunodeficiency virus type 1
isolates was analyzed by a vaccinia virus-based expression and assay system. Usage of …

Macrophage (M)-tropic HIV-1 isolates use the beta-chemokine receptor CCR5 as a
coreceptor for entry, while T cell line-adapted (TCLA) strains use CXCR4 and dual-tropic …

The biological phenotype of primary human immunodeficiency virus type 1 (HIV-1) isolates
varies according to the severity of the HIV infection. Here we show that the two previously …