[HTML][HTML] Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes
P Honkakoski, R Moore, J Gynther, M Negishi - Journal of Biological …, 1996 - Elsevier
The mouse phenobarbital (PB)-inducible Cyp2b10 gene promoter has been isolated and
sequenced, and control of its expression has been characterized. The 1405-base pair (bp) …
sequenced, and control of its expression has been characterized. The 1405-base pair (bp) …
Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene
E Trottier, A Belzil, C Stoltz, A Anderson - Gene, 1995 - Elsevier
Cytochrome P450 2B1, encoded by CYP2B1, and cytochrome P450 2B2, encoded by
CYP2B2, are inducible in rat liver by phenobarbital (PB). We have used cultured adult rat …
CYP2B2, are inducible in rat liver by phenobarbital (PB). We have used cultured adult rat …
The CYP2B1 Proximal Promoter Contains a Functional C/EBP Regulatory Element
Y PARK, B KEMPER - DNA and cell biology, 1996 - liebertpub.com
ABSTRACT Cytochromes P450 2B1 and 2B2 (CYP2B1 and CYP2B2) are well-known
phenobarbital-inducible genes in rat liver. Potential transcriptional regulatory elements in …
phenobarbital-inducible genes in rat liver. Potential transcriptional regulatory elements in …
Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ
Y Park, H Li, B Kemper - Journal of Biological Chemistry, 1996 - ASBMB
The promoter activities of the genes for cytochrome P450 2B1 (CYP2B1) and cytochrome
P450 2C1 (CYP2C1) have been assayed by direct injection of promoter-luciferase chimeric …
P450 2C1 (CYP2C1) have been assayed by direct injection of promoter-luciferase chimeric …
[HTML][HTML] Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice.
R Ramsden, KM Sommer, CJ Omiecinski - Journal of Biological Chemistry, 1993 - Elsevier
To investigate molecular events regulating the transcription of genes inducible by
phenobarbital, transgenic mouse strains were developed incorporating rat cytochrome P450 …
phenobarbital, transgenic mouse strains were developed incorporating rat cytochrome P450 …
A model for the transcriptional regulation of the CYP2B1/B2 gene in rat liver.
L Prabhu, P Upadhya, N Ram… - Proceedings of the …, 1995 - National Acad Sciences
The phenobarbitone-responsive minimal promoter has been shown to lie between nt-179
and nt+ 1 in the 5'(upstream) region of the CYP2B1/B2 gene in rat liver, on the basis of the …
and nt+ 1 in the 5'(upstream) region of the CYP2B1/B2 gene in rat liver, on the basis of the …
Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene
P Honkakoski, M Negishi - Journal of Biological Chemistry, 1997 - ASBMB
Induction of drug-and carcinogen-metabolizing cytochrome P450s by xenobiotic chemicals
is a common cellular defense mechanism, usually leading to increased detoxification of …
is a common cellular defense mechanism, usually leading to increased detoxification of …
Identification and functional characterization of a cis -acting positive DNA element regulating CYP 2B1/B2 gene transcription in rat liver
P Upadhya, MV Rao, V Venkateswar… - Nucleic acids …, 1992 - academic.oup.com
A positive cis-acting DNA element in the near 5'-upstream region of the CYP2B1/B2 genes
in rat liver was found to play an important role in the transcription of these genes. An …
in rat liver was found to play an important role in the transcription of these genes. An …
Transcriptional regulation of the CYP2B1 and CYP2B2 genes by C/EBP-related proteins
PVT Luc, M Adesnik, S Ganguly, PM Shaw - Biochemical pharmacology, 1996 - Elsevier
Cytochrome P450 (CYP) 2B1 and 2B2 are encoded by two closely related genes, CYP2B1
and CYP2B2, that are expressed at low levels in adult rat liver but are induced markedly by …
and CYP2B2, that are expressed at low levels in adult rat liver but are induced markedly by …
Interaction of proteins with a cytochrome P450 2B2 gene promoter: identification of two DNA sequences that bind proteins that are enriched or activated in response to …
EA SHEPHARD, LA FORREST… - DNA and cell …, 1994 - liebertpub.com
Cytochromes P450 (CYPs) are of central importance in the metabolism of foreign
Hydrophobic compounds. Members of the CYP2B subfamily are inducible at the …
Hydrophobic compounds. Members of the CYP2B subfamily are inducible at the …