Methylation is a major regulator of mammalian genome function in vivo. The methylation of
DNA on cytosine residues is a critical component of the host genome defense pathway …

DNA methylation is a heritable epigenetic feature that is associated with transcriptional
silencing, X-chromosome inactivation, genetic imprinting, and genomic stability. The …

Nutrition has always played an important role in health and disease, ranging from common
diseases to its likely contribution to the fetal origins of adult disease. However, deciphering …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

DNA methylation is an important epigenetic mechanism of transcriptional control. DNA
methylation plays an essential role in maintaining cellular function, and changes in …

Many micronutrients and vitamins are critical for DNA synthesis/repair and maintenance of
DNA methylation patterns. Folate has been most extensively investigated in this regard …

Epigenetic changes are inherited alterations in DNA that affect gene expression and
function without altering the DNA sequence. DNA methylation is one epigenetic process …

DNA methylation is the most extensively studied mechanism of epigenetic gene regulation.
Increasing evidence indicates that DNA methylation is labile in response to nutritional and …

Recent studies have demonstrated that methyl insufficiency and/or abnormal DNA
methylation likely have significant roles in the development of several pathologies including …

DNA methylation is a post-replicative, or epigenetic, modification of the genome that is
critical for proper mammalian embryonic development, gene silencing, X chromosome …