Randomized clinical trials (RCTs) are a cornerstone of evidence-based medicine. Their
design, implementation, and interpretation are sometimes subject to flaws and errors. To …

Endpoint selection is a critically important step in clinical trial design. It poses major
challenges for investigators, regulators, and study sponsors, and it also has important …

Background There are different views regarding the appropriateness of using cause-specific
events or all events as the primary outcome of clinical trials. Methods This is a methodologic …

Not that long ago a diagnosis of heart failure was a death sentence. For example, a patient
hospitalized with heart failure in the late 1980s had a median survival of, 1.25 years after …

Background A systematic assessment of the temporal trends in heart failure (HF) clinical
trials is lacking. Methods and Results A total of 154 phase II–IV HF trials including 162,725 …

Current data suggest that patients with HHF have lower inhospital but higher postdischarge
risk for adverse events compared with patients with acute myocardial infarction. The patients …

BACKGROUND: Composite outcomes are commonly used in heart failure trials. The aim of
this article is to discuss the advantages and disadvantages of composite outcomes and …

Background: The usefulness of adjudication by central end point committees (CECs) is
poorly assessed in heart failure (HF) trials. We aimed to assess its impact on the outcome of …

Abstract The Heart Failure Academic Research Consortium is a partnership between the
Heart Failure Collaboratory (HFC) and Academic Research Consortium (ARC), comprised of …

Hospitalization for acute heart failure (AHF) is a major public health problem, with 1 million
hospitalizations annually in the United States. 1 The development of new therapies for …