An obvious paradigm: choosing bronchodilators and inhaled corticosteroids for their pharmacologic characteristics

M Cazzola, MG Matera - Chest, 2021 - journal.chestnet.org
Many clinicians initiate treatment of COPD by prescribing long-acting beta agonist/inhaled
corticosteroid fixed-dose combinations (LABA/ICS FDCs), despite the growing evidence …

Comparative safety and effectiveness of inhaled corticosteroid and long-acting β2-agonist combinations in patients with COPD

TY Chang, JY Chien, CH Wu, YH Dong, FJ Lin - Chest, 2020 - Elsevier
Background The differential risk of pneumonia among inhaled corticosteroid (ICS) use in
patients with COPD requires more investigation, especially regarding beclomethasone …

Inhaled corticosteroids for chronic obstructive pulmonary disease—the shifting treatment paradigm

M Wilkie, S Finch, S Schembri - COPD: Journal of Chronic …, 2015 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) guidelines suggest using inhaled
corticosteroids (ICS) in patients with severe airflow limitation or those at high risk of …

Comparative effectiveness and safety of different types of inhaled long-acting β2-agonist plus inhaled long-acting muscarinic antagonist vs inhaled long-acting β2 …

MT Wang, JH Lai, YL Huang, JT Liou, SH Cheng… - Chest, 2021 - Elsevier
Background Despite multiple available fixed-dose combinations (FDCs) of inhaled long-
acting β 2-agonists (LABAs) plus long-acting muscarinic antagonists (LAMAs) and LABAs …

The impact of inhaled corticosteroid and long-acting β-agonist combination therapy on outcomes in COPD

NA Hanania - Pulmonary pharmacology & therapeutics, 2008 - Elsevier
Chronic obstructive pulmonary disease (COPD) is an under-recognized cause of morbidity
and mortality worldwide that imposes an ever increasing burden on the patient and society …

[HTML][HTML] Overtreatment of COPD with inhaled corticosteroids-implications for safety and costs: cross-sectional observational study

P White, H Thornton, H Pinnock, S Georgopoulou… - PloS one, 2013 - journals.plos.org
Introduction Combined inhaled long-acting beta-agonists and corticosteroids (LABA+ ICS)
are costly. They are recommended in severe or very severe chronic obstructive pulmonary …

Safety and efficacy of combined long-acting β-agonists and inhaled corticosteroids vs long-acting β-agonists monotherapy for stable COPD: a systematic review

GJ Rodrigo, JA Castro-Rodriguez, V Plaza - Chest, 2009 - Elsevier
Background Current guidelines recommend the use of inhaled corticosteroids (ICSs) added
to long-acting β 2-agonists (LABAs) for treatment of symptomatic patients with severe and …

[HTML][HTML] Inhaled corticosteroids are more effective in COPD patients when used with LABA than with SABA

VA Kiri, G Bettoncelli, R Testi, G Viegi - Respiratory medicine, 2005 - Elsevier
Adding long-acting beta agonists (LABA) to inhaled corticosteroids (ICS) has been
associated with beneficial effects in COPD patients in randomized controlled trials and …

Comment on: Combination therapy with long-acting bronchodilators and the risk of major adverse cardiovascular events in patients with COPD: a systematic review …

P Almagro, P Martinez-Camblor - European Respiratory …, 2023 - Eur Respiratory Soc
We read with great interest the meta-analysis recently published in the European
Respiratory Journal by Yang et al.[1] concerning the risk of major adverse cardiovascular …

Real-life use of inhaled corticosteroids in COPD patients versus the GOLD proposals: a paradigm shift in GOLD 2011?

PR Burgel, G Deslée, G Jebrak… - European …, 2014 - Eur Respiratory Soc
Clinical trials in chronic obstructive pulmonary disease (COPD) patients have shown that the
long-term use of inhaled corticosteroids (ICS) in COPD patients reduced the number of …