Aberrations in the DNA methylation patterns are nowadays recognized as a hallmark of
human cancer One of the most characteristic changes is the hypermethylation of CpG …

Cancer is an epigenetic disease at the same level that it can be considered a genetic
disease. In fact, epigenetic changes, particularly DNA methylation, are susceptible to …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …

Most investigations on the role of DNA methylation in cancer have focused on epigenetic
changes associated with known tumor suppressor genes. This may have led to an …

The discovery of global DNA hypomethylation events in human tumors in the early 1980s
and the identification of CpG island promoter hypermethylation of tumor suppressor genes in …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

Epigenetic gene inactivation in transformed cells involves many 'belts of silencing'. One of
the best-known lesions of the malignant cell is the transcriptional repression of tumor …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

CpG islands are associated with at least half of all cellular genes and are normally
methylation-free. Dense methylation of cytosine residues within islands causes strong and …