New indole derivatives as multitarget anti-Alzheimer's agents: synthesis, biological evaluation and molecular dynamics
Background: Alzheimer's disease is a neurological disorder that causes brain cells to shrink
and die. Aim: Thirteen novel 'oxathiolanyl','pyrazolyl'and 'pyrimidinyl'indole derivatives were …
and die. Aim: Thirteen novel 'oxathiolanyl','pyrazolyl'and 'pyrimidinyl'indole derivatives were …
A versatile inhibitory approach and molecular mechanism on cancer cells and cholinesterase enzymes: Synthesis, DFT, ADMET and molecular docking of thiadiazole …
This study presents a multi-routed research design featuring thiadiazole/oxadiazole based
Schiff base derivatives as potential inhibitors, targeting cancer and Alzheimer. Among …
Schiff base derivatives as potential inhibitors, targeting cancer and Alzheimer. Among …
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with multiple factors
associated with its pathogenesis. Our strategy against AD involves design of multi-targeted 2 …
associated with its pathogenesis. Our strategy against AD involves design of multi-targeted 2 …
[HTML][HTML] A Series of Novel 1-H-isoindole-1, 3 (2H)-dione Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: In Silico, Synthesis and In Vitro …
E Krzyżak, A Marciniak, D Szkatuła, KA Jankowska… - …, 2024 - pmc.ncbi.nlm.nih.gov
Abstract The derivatives of isoindoline-1, 3-dione are interesting due to their biological
activities, such as anti-inflammatory and antibacterial effects. Several series have been …
activities, such as anti-inflammatory and antibacterial effects. Several series have been …
Synthesis of indole derivatives as Alzheimer inhibitors and their molecular docking study
Acetylcholinesterase prevails in the healthy brain, with butyrylcholinesterase reflected to
play a minor role in regulating brain acetylcholine (ACh) levels. However, BuChE activity …
play a minor role in regulating brain acetylcholine (ACh) levels. However, BuChE activity …
Design, synthesis, in vitro acetylcholinesterase, butyrylcholinesterase activities, and in silico molecular docking study of oxindole-oxadiazole hybrid analogues
Alzheimer's disease is a neurological disorder characterized by cognitive dysfunction and
deficits in activities of daily living. There is no drug available for Alzheimer's at the moment …
deficits in activities of daily living. There is no drug available for Alzheimer's at the moment …
[HTML][HTML] A promising acetylcholinesterase and butyrylcholinesterase inhibitors: In vitro enzymatic and in silico molecular docking studies of benzothiazole-based …
Abstract Alzheimer's dementia (AD), the most prevalent neurodegenerative disorder
adversely affecting elderly citizens worldwide, is an incurable disorder with no effective …
adversely affecting elderly citizens worldwide, is an incurable disorder with no effective …
Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer's agents: synthesis, in-silico and pharmacological evaluations
Alzheimer's disease (AD) is a multifaceted neurodegenerative condition. The pathogenesis
of AD is highly intricate and the disease is apparent in the aged population~ 50–70 years …
of AD is highly intricate and the disease is apparent in the aged population~ 50–70 years …
Design and synthesis of new indole drug candidates to treat Alzheimer's disease and targeting neuro-inflammation using a multi-target-directed ligand (MTDL) …
PF Lamie, MM Abdel-Fattah… - Journal of enzyme …, 2022 - Taylor & Francis
A novel series of indole-based compounds was designed, synthesised, and evaluated as
anti-Alzheimer's and anti-neuroinflammatory agents. The designed compounds were in vitro …
anti-Alzheimer's and anti-neuroinflammatory agents. The designed compounds were in vitro …
Inhibition, ADME and structure based modification of IAA and IBA against acetylcholinesterase: an attempt towards new drug development for Alzheimer's disease
Indole derived compounds have gained considerable attention in the pharmaceutical
industry due to their pharmacological and structural properties. Indole-3-acetic acid (IAA) …
industry due to their pharmacological and structural properties. Indole-3-acetic acid (IAA) …