Transient receptor potential (TRP) channels in the airway: role in airway disease

MS Grace, M Baxter, E Dubuis… - British journal of …, 2014 - Wiley Online Library
Over the last few decades, there has been an explosion of scientific publications reporting
the many and varied roles of transient receptor potential (TRP) ion channels in physiological …

[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease

K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

TRP channel and cardiovascular disease

H Watanabe, M Murakami, T Ohba, Y Takahashi… - Pharmacology & …, 2008 - Elsevier
The transient receptor potential (TRP) channel superfamily consists of 28 mammalian cation
channels and is expressed in almost every tissue, including the heart and vasculature; most …

Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels

BR Bianchi, XF Zhang, RM Reilly, PR Kym… - … of Pharmacology and …, 2012 - ASPET
The transient receptor potential ankyrin-1 (TRPA1) channel has emerged as an attractive
target for development of analgesic and anti-inflammatory drugs. However, drug discovery …

[HTML][HTML] TRP channels and pain

DN Cortright, JE Krause, DC Broom - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
Since the molecular identification of the capsaicin receptor, now known as TRPV1, transient
receptor potential (TRP) channels have occupied an important place in the understanding of …

TRP channels as therapeutic targets in airway disorders: a patent review

D Preti, A Szallasi, R Patacchini - Expert opinion on therapeutic …, 2012 - Taylor & Francis
Introduction: Chronic respiratory diseases, such as asthma and chronic obstructive
pulmonary disease, affect millions of patients worldwide. New therapeutic approaches to …

TRPV1 shows dynamic ionic selectivity during agonist stimulation

MK Chung, AD Güler, MJ Caterina - Nature neuroscience, 2008 - nature.com
Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious
heat, capsaicin and other diverse stimuli. It is a nonselective cation channel that prefers …

Expression and distribution of TRPV2 in rat brain

TP Nedungadi, M Dutta, CS Bathina, MJ Caterina… - Experimental …, 2012 - Elsevier
Transient receptor potential (TRP) proteins are non-selective cation channels that mediate
sensory transduction. The neuroanatomical localization and the physiological roles of …

Regulation of TRP channels by phosphorylation

X Yao, HY Kwan, Y Huang - Neurosignals, 2006 - karger.com
The transient receptor potential (TRP) channels are a group of Ca2+-permeable cation
channels (except TRPM4 and TRPM5) that function as cellular sensors of various internal …

Introduction to TRP channels: structure, function, and regulation

MY Song, JXJ Yuan - Membrane Receptors, Channels and Transporters …, 2010 - Springer
Transient receptor potential or TRP families of ion channels demonstrate great diversity in
activation and inhibition, and they are diverse in selectivity of ion conductance. TRP ion …