Background and Purpose—Diaspirin cross-linked hemoglobin (DCLHb) is a purified, cell-
free human hemoglobin solution. In animal stroke models its use led to a significant …

Hemodilution using modified hemoglobin solutions may reduce ischemic central nervous
system injury. Purified diaspirin cross-linked hemoglobin (DCLHb) is a cell-free hemoglobin …

Diaspirin cross-linked hemoglobin (DCLHb; Baxter Healthcare Corp., Blood Substitutes
Division) is a promising hemoglobin-based oxygen-carrying resuscitative solution. DCLHb …

Hemodilution has had limited success as a treatment of cerebral ischemia. When using a
nonoxygen binding fluid, the therapeutic efficacy of hemodilution-induced increases in CBF …

The purpose of this investigation was to compare the effects of initial resuscitation with
HBOC-201 to that of lactated Ringer (LR) solution in the setting of uncontrolled hemorrhage …

Diaspirin cross-linked hemoglobin (DCLHb TM), a hemoglobin-based blood substitute, has
been found to improve systemic hemodynamics, cutaneous oxygen tension, and …

Diaspirin crosslinked hemoglobin solution (DCLHbTM) has potential for clinical use as an
oxygen-carrying solution because of its excellent oxygen transport properties and …

Blood transfusion is the key life-saving treatment in many traumatic emergencies, chronic or
acute pathologies, and during or upon surgical interventions. The primary goal of blood …

This article addresses issues involved in the development of hemoglobin-based oxygen
carriers and provides a focused overview of the 4 hemoglobin-based oxygen carriers with …

ContextSevere, uncompensated, traumatic hemorrhagic shock causes significant morbidity
and mortality, but resuscitation with an oxygen-carrying fluid might improve patient …