Evaluation of the serum N‐linked glycome for the diagnosis of cancer and chronic inflammation
The identification of serum biomarkers has lead to improvements in the detection and
diagnosis of cancer, and combinations of these biomarkers have increased further their …
diagnosis of cancer, and combinations of these biomarkers have increased further their …
Glycans as cancer biomarkers
B Adamczyk, T Tharmalingam, PM Rudd - Biochimica et Biophysica Acta …, 2012 - Elsevier
BACKGROUND: Non-invasive biomarkers, such as those from serum, are ideal for disease
prognosis, staging and monitoring. In the past decade, our understanding of the importance …
prognosis, staging and monitoring. In the past decade, our understanding of the importance …
Glycosylation‐based serum biomarkers for cancer diagnostics and prognostics
A Kirwan, M Utratna, ME O'Dwyer… - BioMed research …, 2015 - Wiley Online Library
Cancer is the second most common cause of death in developed countries with
approximately 14 million newly diagnosed individuals and over 6 million cancer‐related …
approximately 14 million newly diagnosed individuals and over 6 million cancer‐related …
A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression
UM Abd Hamid, L Royle, R Saldova, CM Radcliffe… - …, 2008 - academic.oup.com
Aberrant glycosylation on glycoproteins that are either presented on the surface or secreted
by cancer cells is a potential source of disease biomarkers and provides insights into …
by cancer cells is a potential source of disease biomarkers and provides insights into …
[HTML][HTML] Serum N-glycome alterations in colorectal cancer associate with survival
SW de Vroome, S Holst, MR Girondo… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Proteins are routinely measured in clinical laboratories for diagnosis, prognosis and therapy
monitoring. Nevertheless, both test improvements (performance) and innovations …
monitoring. Nevertheless, both test improvements (performance) and innovations …
Ultra Performance Liquid Chromatographic Profiling of Serum N-Glycans for Fast and Efficient Identification of Cancer Associated Alterations in Glycosylation
J Bones, S Mittermayr, N O'Donoghue… - Analytical …, 2010 - ACS Publications
Glycosylation is a diverse but critically important post-translational modification that
modulates the physical, chemical and biological properties of proteins. Alterations in …
modulates the physical, chemical and biological properties of proteins. Alterations in …
Novel glycan biomarkers for the detection of lung cancer
JN Arnold, R Saldova, MC Galligan… - Journal of proteome …, 2011 - ACS Publications
Lung cancer has a poor prognosis and a 5-year survival rate of 15%. Therefore, early
detection is vital. Diagnostic testing of serum for cancer-associated biomarkers is a …
detection is vital. Diagnostic testing of serum for cancer-associated biomarkers is a …
Breast cancer diagnosis and prognosis through quantitative measurements of serum glycan profiles
Background: Glycosylated proteins play important roles in cell-to-cell interactions,
immunosurveillance, and a variety of receptor-mediated and specific protein functions …
immunosurveillance, and a variety of receptor-mediated and specific protein functions …
A strategy for discovery of cancer glyco‐biomarkers in serum using newly developed technologies for glycoproteomics
Detection of cancer at early stages that can be treated through surgery is a difficult task. One
methodology for cancer biomarker discovery exploits the fact that glycoproteins produced by …
methodology for cancer biomarker discovery exploits the fact that glycoproteins produced by …
Screening of glycosylation patterns in serum using natural glycoprotein microarrays and multi-lectin fluorescence detection
TH Patwa, J Zhao, MA Anderson, DM Simeone… - Analytical …, 2006 - ACS Publications
Protein glycosylation has been implicated in key biological processes including
immunological recognition, cellular adhesion, protein folding, and signaling as well as …
immunological recognition, cellular adhesion, protein folding, and signaling as well as …