[HTML][HTML] Lack of group X secreted phospholipase A2 increases survival following pandemic H1N1 influenza infection
The role of Group X secreted phospholipase A 2 (GX-sPLA 2) during influenza infection has
not been previously investigated. We examined the role of GX-sPLA 2 during H1N1 …
not been previously investigated. We examined the role of GX-sPLA 2 during H1N1 …
Secreted phospholipase PLA2G2E contributes to regulation of T cell immune response against influenza virus infection
H Bu, S Zhang, P Li, Z Liu, Y Liu, Z Li, X Liu… - Journal of …, 2024 - Am Soc Microbiol
The involvement of secreted phospholipase A2s in respiratory diseases, such as asthma
and respiratory viral infections, is well-established. However, the specific role of secreted …
and respiratory viral infections, is well-established. However, the specific role of secreted …
Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective …
WR Henderson, RC Oslund, JG Bollinger, X Ye… - Journal of Biological …, 2011 - ASBMB
Group X (GX) phospholipase A 2, a member of a large group of secreted phospholipases A
2 (sPLA 2 s), has recently been demonstrated to play an important in vivo role in the release …
2 (sPLA 2 s), has recently been demonstrated to play an important in vivo role in the release …
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection
Oxidative stress and chronic low-grade inflammation in the lungs are associated with aging
and may contribute to age-related immune dysfunction. To maintain lung homeostasis …
and may contribute to age-related immune dysfunction. To maintain lung homeostasis …
What do secreted phospholipases A2 have to offer in combat against different viruses up to SARS-CoV-2?
Secreted phospholipases A 2 (sPLA 2 s) form a widespread group of structurally-related
enzymes that catalyse the hydrolysis of the sn-2 ester bond of glycerophospholipids to …
enzymes that catalyse the hydrolysis of the sn-2 ester bond of glycerophospholipids to …
Group V Phospholipase A2 Mediates Endothelial Dysfunction and Acute Lung Injury Caused by Methicillin-Resistant Staphylococcus Aureus
Lung endothelial dysfunction is a key feature of acute lung injury (ALI) and clinical acute
respiratory distress syndrome (ARDS). Previous studies have identified the lipid-generating …
respiratory distress syndrome (ARDS). Previous studies have identified the lipid-generating …
Temporal associations of plasma levels of the secreted phospholipase A2 family and mortality in severe COVID‐19
Previous research suggests that group IIA‐secreted phospholipase A2 (sPLA2‐IIA) plays a
role in and predicts lethal COVID‐19 disease. The current study reanalyzed a longitudinal …
role in and predicts lethal COVID‐19 disease. The current study reanalyzed a longitudinal …
Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice
NM Muñoz, AY Meliton, LN Meliton… - … of Physiology-Lung …, 2009 - journals.physiology.org
We investigated the regulatory role of 14-kDa secretory group V phospholipase A2
(gVPLA2) in the development of acute lung injury (ALI) and neutrophilic inflammation (NI) …
(gVPLA2) in the development of acute lung injury (ALI) and neutrophilic inflammation (NI) …
Phosphatidylserine-Specific Phospholipase A1 Alleviates Lipopolysaccharide-Induced Macrophage Inflammation by Inhibiting MAPKs Activation
W Zhang, C Liu, M Wang, Z Yang, J Yang… - Biological and …, 2022 - jstage.jst.go.jp
Macrophages are a key in innate immune responses and play vital roles in homeostasis and
inflammatory diseases. Phosphatidylserine-specific phospholipase A1 (PS-PLA1) is a …
inflammatory diseases. Phosphatidylserine-specific phospholipase A1 (PS-PLA1) is a …
[PDF][PDF] Interaction of secreted phospholipase A2 and pulmonary surfactant and its pathophysiological relevance in acute respiratory distress syndrome
L Touqui, YZ Wu - Acta Pharmacologica Sinica, 2003 - cdn.amegroups.cn
Phospholipases A2 (PLA2s) belong to a family of enzymes that hydrolyze phospholipids at
the sn-2 position leading to the liberation of fatty acids and lysophospholipids (Fig 1) …
the sn-2 position leading to the liberation of fatty acids and lysophospholipids (Fig 1) …