Brain region-specific reduction in c-Fos expression associated with an anxiolytic effect of yokukansan in rats

H Shoji, K Mizoguchi - Journal of ethnopharmacology, 2013 - Elsevier
Ethnopharmacological relevance A traditional Japanese (Kampo) medicine, yokukansan,
has long been used to treat neurosis, insomnia, and night crying and irritability in children …

Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress

T Yamaguchi, A Tsujimatsu, H Kumamoto… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Yokukansan, a traditional Japanese medicine
(Kampo), has been reported in the treatment of behavioral and psychological symptoms of …

Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats

H Kanno, K Sekiguchi, T Yamaguchi… - Journal of Pharmacy …, 2009 - academic.oup.com
Abstract Objectives Yokukansan, a traditional Japanese medicine, has been approved by
the Ministry of Health, Labour, and Welfare of Japan as a remedy for neurosis, insomnia or …

Anxiolytic effect of a herbal medicine, yokukansan, in aged rats: involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex

K Mizoguchi, Y Tanaka, T Tabira - Journal of ethnopharmacology, 2010 - Elsevier
AIM OF THE STUDY: Aging is thought to affect emotions including anxiety, and a herbal
medicine, yokukansan (YKS), is used to treat emotional disturbances associated with age …

Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice

T Ueki, K Mizoguchi, T Yamaguchi, A Nishi… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance Yokukansan, a traditional Japanese (Kampo) medicine,
has recently been used to treat the behavioral and psychological symptoms of dementia …

Yokukansan, a traditional Japanese herbal medicine, enhances the anxiolytic effect of fluvoxamine and reduces cortical 5-HT2A receptor expression in mice

R Ohno, H Miyagishi, M Tsuji, A Saito… - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance Yokukansan is a traditional Japanese herbal medicine
that has been approved in Japan as a remedy for neurosis, insomnia, and irritability in …

[HTML][HTML] Yokukansan and yokukansankachimpihange ameliorate aggressive behaviors in rats with cholinergic degeneration in the nucleus basalis of meynert

M Tabuchi, K Mizuno, K Mizoguchi, T Hattori… - Frontiers in …, 2017 - frontiersin.org
Yokukansan (YKS) and yokukansankachimpihange (YKSCH) are traditional Japanese
Kampo medicines. The latter comprises YKS along with the medicinal herbs Citrus unshiu …

Neuroprotective effect of yokukansan against cytotoxicity induced by corticosterone on mouse hippocampal neurons

Y Nakatani, M Tsuji, T Amano, K Miyagawa… - Phytomedicine, 2014 - Elsevier
Yokukansan, a traditional Japanese herbal medicine, has been used for the management of
neurodegenerative disorders and for the treatment of neurosis, insomnia, and behavioral …

[HTML][HTML] Multiple psychopharmacological effects of the traditional Japanese Kampo medicine Yokukansan, and the brain regions it affects

K Mizoguchi, Y Ikarashi - Frontiers in Pharmacology, 2017 - frontiersin.org
Yokukansan (YKS), a traditional Japanese Kampo medicine, has indications for use in night
crying and irritability in children, as well as neurosis and insomnia. It is currently also used …

Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats

A Takeda, H Itoh, H Tamano, M Yuzurihara… - Nutritional …, 2008 - Taylor & Francis
Abstract Yokukansan (TJ-54), a herbal medicine, has been used as a cure for insomnia and
irritability in children. Yokukansan also improves behavioral and psychological symptoms …