Chlamydia possesses a conserved 7.5 kb plasmid that is known to play an important role in
chlamydial pathogenesis, since some chlamydial organisms lacking the plasmid are …

Chlamydia trachomatis and C. muridarum are human and mouse pathogens, respectively,
which show high conservation of gene order and content. Both species contain a common …

Plasmid transformation of chlamydiae has created new opportunities to investigate host–
microbe interactions during chlamydial infections; however, there are still limitations …

The genus Chlamydia consists of diverse, obligate intracellular bacteria that infect various
animals, including humans. Although chlamydial species share many aspects of the typical …

The recent success in transformation of Chlamydia trachomatis represents a major
advancement in Chlamydia research. Plasmid-free C. trachomatis serovar L2 organisms can …

Background: Research in chlamydial genetics is challenging because of its obligate
intracellular developmental cycle. In vivo systems exist that allow studies of different aspects …

Functional genetic analysis of Chlamydia has been a challenge due to the historical genetic
intractability of Chlamydia, although recent advances in chlamydial genetic manipulation …

Transformation of Chlamydia trachomatis should greatly advance the chlamydial research.
However, significant progress has been hindered by the failure of C. trachomatis to induce …

The development of genetic transformation technology for Chlamydia trachomatis using its
endogenous plasmid has recently been described. Chlamydia muridarum cannot be …

A highly conserved cryptic plasmid is present in Chlamydia trachomatis yet naturally
occurring plasmid-deficient isolates are very rare. This paper describes the isolation and …