The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-
induced synaptic modification. Here we examined whether plasticity of orientation selectivity …

Visual stimuli are known to induce various changes in the receptive field properties of adult
cortical neurons, but the underlying mechanisms are not well understood. Repetitive pairing …

Receptive field properties of visual cortical neurons depend on the spatiotemporal context
within which the stimuli are presented. We have examined the temporal context dependence …

Primary visual cortex (V1) is the site at which orientation selectivity emerges in mammals:
visual thalamus afferents to V1 respond equally to all stimulus orientations, whereas their …

In the adult brain, sensory cortical neurons undergo transient changes of their response
properties following prolonged exposure to an appropriate stimulus (adaptation). In cat V1 …

Use-dependent long-term changes of neuronal response properties must be gated to
prevent irrelevant activity from inducing inappropriate modifications. Here we test the …

Adaptation-induced changes in the temporal-frequency tuning and direction selectivity of cat
visual cortical cells were studied. Aftereffects were induced largely independent of direction …

We have studied the precise temporal requirements for plasticity of orientation preference
maps in kitten visual cortex. Pairing a brief visual stimulus with electrical stimulation in the …

A key emergent property of the primary visual cortex (V1) is the orientation selectivity of its
neurons. The extent to which adult visual cortical neurons can exhibit changes in orientation …

Neurons in the primary visual cortex are highly selective for stimulus orientation, whereas
their thalamic inputs are not. Much controversy has been focused on the mechanism by …