Upon stimulation, B cells assume heterogeneous cell fates, with only a fraction
differentiating into antibody-secreting cells (ASC). Here we investigate B cell fate …

Differentiation of B cells into antibody-secreting cells (ASCs) is a key process to generate
protective humoral immunity. A detailed understanding of the cues controlling ASC …

When B cells encounter an antigen, they alter their physiological state and anatomical
localization and initiate a differentiation process that ultimately produces antibody-secreting …

Antibodies on the surface of B lymphocytes trigger adaptive immune responses and control
a series of antigen-independent checkpoints during B cell development. These physiologic …

Antibody‐secreting cells (ASCs) play a fundamental role in humoral immunity. The aberrant
function of ASCs is related to a number of disease states, including autoimmune diseases …

Regulatory B cells have largely been reported as B cells at a developmental stage before
plasma cell differentiation. Matsumoto et al.(2014) report that IL-10+ plasmablasts restrain …

Although autoantigen-induced negative selection plays an important role in shaping the
mature B-cell repertoire, studies in recent years have suggested that differentiation into any …

Protective humoral memory forms in secondary lymphoid organs where B cells undergo
affinity maturation and differentiation into memory or plasma cells. Here, we provide a …

B-1a cells are long-lived, self-renewing innate-like B cells that predominantly inhabit the
peritoneal and pleural cavities. In contrast to conventional B-2 cells, B-1a cells have a …

Upon recognition of antigen, B cells undertake a bifurcated response in which some cells
rapidly differentiate into plasmablasts while others undergo affinity maturation in germinal …