[HTML][HTML] Impact of aging on viral infections

J Leng, DR Goldstein - Microbes and infection, 2010 - Elsevier
Older people are more susceptible to a variety of viral infections, including those that induce
respiratory disease, resulting in higher morbidity and mortality than younger people. Aging …

Role of aging on innate responses to viral infections

DR Goldstein - Journals of Gerontology Series A: Biomedical …, 2012 - academic.oup.com
Older people exhibit increased morbidity and mortality after viral infections than younger
people. Additionally, vaccines are less protective in older people than in younger people. As …

[HTML][HTML] Aging and options to halt declining immunity to virus infections

MÁ Palacios-Pedrero, ADME Osterhaus… - Frontiers in …, 2021 - frontiersin.org
Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

[HTML][HTML] Aging of the immune system: research challenges to enhance the health span of older adults

L Haynes - Frontiers in aging, 2020 - frontiersin.org
The world's population is aging, which brings about huge scientific challenges. Since the
biological process of aging is by far the greatest risk factor for most chronic diseases …

Persistent viral infections and immune aging

S Brunner, D Herndler-Brandstetter, B Weinberger… - Ageing research …, 2011 - Elsevier
Immunosenescence comprises a set of dynamic changes occurring to both, the innate as
well as the adaptive immune system that accompany human aging and result in complex …

Effects of aging on the adaptive immune response to respiratory virus infections

RB Fulton, SM Varga - Aging health, 2009 - Taylor & Francis
Severe acute respiratory disease caused by respiratory virus infections in individuals aged
65 years and older and in high-risk adults, such as those with chronic cardiopulmonary …

Understanding immunosenescence and its impact on vaccination of older adults

JC Allen, FR Toapanta, W Chen, SM Tennant - Vaccine, 2020 - Elsevier
Older adults are more susceptible to viral and bacterial infection, and experience higher
incidence and severity of infectious diseases. Although vaccination is the most logical …

Ageing and respiratory infections: the airway of ageing

K Haq, JE McElhaney - Immunology letters, 2014 - Elsevier
Respiratory infections are a leading cause of infectious disease burden worldwide
especially among the elderly. Furthermore, a direct relationship between ageing and …

Innate immune responses in the ageing lung

DM Boe, LA Boule, EJ Kovacs - Clinical & Experimental …, 2017 - academic.oup.com
The world is undergoing an unprecedented shift in demographics, with the number of
individuals over the age of 60 years projected to reach 2 billion or more by 2050 …

[HTML][HTML] Ineffective humoral immunity in the elderly

KS McGlauchlen, LA Vogel - Microbes and infection, 2003 - Elsevier
As individuals age, dysfunction of the immune system leads to an increased incidence of
infectious disease. Due to the complex network of cellular interactions and the multi-factorial …