Angiogenesis is a promising target for the development of effective strategies for the
treatment of malignant brain tumors in that it has the potential to starve large tumors and …

The formation of tumor vasculature and cell invasion along white matter tracts have pivotal
roles in the development and progression of glioma. A better understanding of the …

The ECM of astrocytic tumors promotes and modulates a variety of cell functions, such as
cell attachment, migration, proliferation, survival, and signaling. Recent studies indicate that …

Angiogenesis and tumor cell invasion are pathophysiological processes playing a pivotal
role in glioma development and growth since the earliest phase. Angiogenesis and tumor …

Tumor development is a complex process that relies on interaction and communication
between a number of cellular compartments. Much of the mass of a solid tumor is comprised …

Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its
progression-free survival. However, current antiangiogenic therapy induces serious adverse …

Malignant gliomas are primary brain tumors, which are highly invasive but not known to
metastasize outside the central nervous system (CNS). The median survival time of patients …

The communication between tumor cells and extracellular matrix (ECM) is responsible for
clinically important features of malignant gliomas, such as cerebral invasion and …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

Malignant human gliomas are characterized by an uncontrolled cell proliferation and
infiltrative growth within the brain. Complete surgical removal is difficult due to disseminated …