The retinoblastoma gene (RB1) is a recessive oncogene implicated in a number of human
tumors. Although the RB1 gene is expressed in most proliferating cells, there is considerable …

The product of the retinoblastoma gene (RB1) is believed to function as a negative regulator
of cell growth. Recent experimental results suggest that RB1 may exert its growth …

We report the isolation and characterization of the mouse RB1 promoter and surrounding
DNA sequences, and the identification of elements required for basal transcriptional activity …

The retinoblastoma gene product, pRB, regulates cell proliferation by binding to and
inhibiting the activity of key growth promoting proteins. Several cellular proteins have been …

Inactivation of the retinoblastoma gene (RB gene) is associated with the development of
several human malignancies including retinoblastomas, some osteo-and soft tissue …

Inactivation of both alleles of the RB1 gene during normal retinal development initiates the
formation of a retinoblastoma (RB) tumor. To identify the mutations which inactivate RB1, 21 …

Retinoblastoma, an uncommon childhood cancer of the eye, sometimes occurs in families
but is often sporadic. Cytological analysis suggested that the retinoblastoma gene resided …

Publisher Summary Retinoblastoma is a childhood ocular tumor that can be either heritable
or nonheritable. The cellular origin of retinoblastoma is a precursor of the neuroepithelial …

The retinoblastoma (Rb) gene is a recessive oncogene or tumor-suppressor gene whose
inactivation leads to the development of tumors. Recently, evidence pointing to a role for the …

We previously reported two oncogenic point mutations present in the RB (retinoblastoma)
gene promoter region, found at consensus Sp1 and ATF sites, respectively, and in two …