One-pot preparation of polyethylenimine-silica nanoparticles as serum-resistant gene delivery vectors: Intracellular trafficking and transfection

WT He, YN Xue, N Peng, WM Liu, RX Zhuo… - Journal of Materials …, 2011 - pubs.rsc.org
Organic-inorganic hybrid silica nanoparticles (PM-1, PM-2 and PM-3) with positive surface
charge and size below 200 nm were one-pot prepared viaMichael addition between 3 …

The serum-resistant transfection evaluation and long-term stability of gene delivery dry powder based on mesoporous silica nanoparticles and polyethyleneimine by …

X Zhang, J Zhang, G Quan, P Yang, X Pan, C Wu - AAPS PharmSciTech, 2017 - Springer
Mesoporous silica nanoparticles (MSNs) with large surface area, tunable pore size, and low
toxicity can act as suitable vehicles for drug and gene delivery. An MSN/DNA/PEI complex …

Mannosylated polyethylenimine coupled mesoporous silica nanoparticles for receptor-mediated gene delivery

IY Park, IY Kim, MK Yoo, YJ Choi, MH Cho… - International journal of …, 2008 - Elsevier
Organic–inorganic nanohybrids have been studied for their use as non-viral transfection
agents. The purpose of this study was to examine the ability of mesoporous silica …

Enhanced gene delivery by polyethyleneimine coated mesoporous silica nanoparticles

H Zarei, R Kazemi Oskuee… - Pharmaceutical …, 2019 - Taylor & Francis
Due to large surface area, tunable pore size, easy surface manipulation, and low-toxicity
mesoporous silica nanoparticles (MSNs) may act as a suitable vector for gene delivery. In …

A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro

C Kneuer, M Sameti, U Bakowsky… - Bioconjugate …, 2000 - ACS Publications
Diverse polycationic polymers have been used as nonviral transfection agents. Here we
report the ability of colloidal silica particles with covalently attached cationic surface …

Biocompatibility of poly-l-lysine-modified silica nanoparticles

SG Zhu, K Gan, Z Li, SR Shen, JJ Xiang… - Ai Zheng= Aizheng …, 2003 - europepmc.org
BACKGROUND & OBJECTIVE: Poly-l-lysine-modified silica nanoparticle (PMS-NP) was a
novel non-viral vector for gene delivery. The current study was designed to evaluate the …

Silica nanoparticles modified with aminosilanes as carriers for plasmid DNA

C Kneuer, M Sameti, EG Haltner, T Schiestel… - International journal of …, 2000 - Elsevier
We synthesised silica nanoparticles (SiNP) with covalently linked cationic surface
modifications and demonstrated their ability to electrostatically bind, condense and protect …

Promising plasmid DNA vector based on APTES-modified silica nanoparticles

T Cheang, B Tang, A Xu, G Chang, Z Hu… - International journal …, 2012 - Taylor & Francis
Nanoparticles have an enormous potential for development in biomedical applications, such
as gene or drug delivery. We developed and characterized aminopropyltriethoxysilane …

Cationic silica nanoparticles as gene carriers: synthesis, characterization and transfection efficiency in vitro and in vivo

MNV Kumar, M Sameti, SS Mohapatra… - … of nanoscience and …, 2004 - ingentaconnect.com
The potential of cationic SiO2 nanoparticles was investigated for in vivo gene transfer in this
study. Cationic SiO2 nanoparticles with surface modification were generated using amino …

Promising gene delivery system based on polyethylenimine-modified silica nanoparticles

M Babaei, H Eshghi, K Abnous, M Rahimizadeh… - Cancer Gene …, 2017 - nature.com
This article reports on the synthesis and full characterization of innovative silica-based
nanoparticle composed of fumed silica as a core decorated with polyethylenimine (PEI) with …