The retinoblastoma protein interacts with a number of cellular proteins to form complexes
which are probably crucial for its normal physiological function. To identify these proteins …

The retinoblastoma gene product, pRB, regulates cell proliferation by binding to and
inhibiting the activity of key growth promoting proteins. Several cellular proteins have been …

E2F is a transcription factor that helps regulate the expression of a number of genes that are
important in cell proliferation. Recently, several laboratories have isolated a cDNA clone that …

The product of the retinoblastoma tumor suppressor gene interacts with the transcription
factor E2F. Two distinct types of interactions can be detected between the retinoblastoma …

The retinoblastoma protein (pFl6) plays an important role in the control of cell proliferation,
apparently by binding to and regulating cellular transcription factors such as E2F. Here we …

Studies of naturally occurring mutations of the RB1 tumor suppressor gene have indicated
that the E1A/T antigen-binding domain is important for pRb function. Mutations engineered …

An expression vector was modified to permit the rapid synthesis of purified, UP-labeled,
glutathione S-transferase (GST)-retinoblastoma (RB) fusion proteins. The products were …

Despite the importance of the retinoblastoma susceptibility gene to tumor growth control, the
structural features of its encoded protein (pRb) and their relationship to protein function have …

The cellular transcription factor E2F appears to be a target for the regulatory action of the
retinoblastoma tumor suppressor gene product. The recent isolation of the E2F1 cDNA …

Even though the retinoblastoma gene is one of the best-studied tumor suppressor genes,
little is known about its functional role. Like all tumor suppressor gene products, the …