Negative regulation of p53 by the long isoform of ErbB3 binding protein Ebp1 in brain tumors

CK Kim, TLX Nguyen, KM Joo, DH Nam, J Park… - Cancer research, 2010 - AACR
Abstract The ErbB3 binding protein Ebp1 has been implicated in a number of human
cancers. Ebp1 includes 2 isoforms, p48 and p42, that exhibit different cellular activities. Here …

Phosphorylation of the N‐terminal domain of p48 Ebp1 by CDK2 is required for tumorigenic function of p48

HR Ko, CK Kim, JY Ahn - Molecular carcinogenesis, 2015 - Wiley Online Library
The long isoform of ErbB3 binding protein 1 (Ebp1), p48, strongly promotes tumorigenesis of
glioblastoma, accelerating cell proliferation and transformation, while the short isoform, p42 …

Ebp1 isoforms distinctively regulate cell survival and differentiation

Z Liu, JY Ahn, X Liu, K Ye - Proceedings of the National …, 2006 - National Acad Sciences
Ebp1, an ErbB3 receptor-binding protein, inhibits the proliferation and induces the
differentiation of human cancer cells. Ebp1 binds nuclear Akt and prevents DNA …

Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization

CK Kim, SB Lee, TLX Nguyen, KH Lee, SH Um… - Experimental cell …, 2012 - Elsevier
p48 is a long isoform of the ErbB3 binding protein that has oncogenic functions including
promotion of carcinogenesis and induction of malignant transformation through negative …

The roles of multifunctional protein ErbB3 binding protein 1 (EBP1) isoforms from development to disease

I Hwang, HR Ko, JY Ahn - Experimental & Molecular Medicine, 2020 - nature.com
The roles of the two isoforms of ErbB3-binding protein 1 (Ebp1) in cellular function and its
regulation in disease and development is a stimulating area in current fields of biology, such …

Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor

Z Liu, SM Oh, M Okada, X Liu, D Cheng… - Molecular Biology of …, 2009 - Am Soc Cell Biol
Human Bre1, an E3 ligase for H2B monoubiquitination, binds p53 and enhances activator-
dependent transcription. Ebp1, an ErbB3 receptor-binding protein, inhibits cell proliferation …

Opposing roles of the two isoforms of ErbB3 binding protein 1 in human cancer cells

HR Ko, YS Chang, WS Park… - International journal of …, 2016 - Wiley Online Library
The different functions of the two isoforms of ErbB3 binding protein 1 (Ebp1), p48 and p42,
have recently become the focus of interest as they reveal contradictory roles in cell growth …

The role of ErbB3 binding protein 1 in cancer: Friend or foe?

DQ Nguyen, DH Hoang, TT Nguyen Vo… - Journal of cellular …, 2018 - Wiley Online Library
ErbB3, a member of the epidermal growth factor receptor family, reportedly plays an
essential role in the regulation of cancer progression and therapeutic resistance. Numerous …

Ebp1-mediated inhibition of cell growth requires serine 363 phosphorylation

D Akinmade, M Lee, Y Zhang… - … journal of oncology, 2007 - spandidos-publications.com
Ebp1 is an ErbB3 binding phosphoprotein with pleiotropic effects. Overexpression of Ebp1
represses transcription of E2F1 responsive cell cycle regulated genes and inhibits cell …

The downregulation of ErbB3 binding protein 1 (EBP1) is associated with poor prognosis and enhanced cell proliferation in hepatocellular carcinoma

B Hu, Y Xiong, R Ni, L Wei, D Jiang, G Wang… - Molecular and cellular …, 2014 - Springer
Abstract ErbB3 binding protein 1 (EBP1) has been recently reported to function as a tumor
suppressor in the progression of multiple cancers, including breast cancer, prostate cancer …