Although it is widely accepted that the regulation of the chromatin landscape is pivotal to
conveying the epigenetic program, it is still unclear how a defined chromatin domain is …

Organisms with the same genome can inherit information in addition to that encoded in the
DNA sequence—this is known as epigenetic inheritance. Epigenetic inheritance is …

Studies in eukaryotes ranging from yeast to mammals indicate that specific chromatin
structures can be inherited following DNA replication via mechanisms acting in cis. Both the …

Multiple circuitries ensure that cells respond correctly to the environmental cues within
defined cellular programs. There is increasing evidence suggesting that cellular memory for …

The mechanisms by which stable gene expression patterns are inherited during cell division
are not well understood. Chromatin is subject to a number of covalent modifications and it is …

Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Studies that concern the mechanism of DNA replication have provided a major framework
for understanding genetic transmission through multiple cell cycles. Recent work has begun …

Cells of a multicellular organism, all containing nearly identical genetic information, respond
to differentiation cues in variable ways. In addition, cells are plastic, able to execute their …

Propagation of the chromatin landscape across cell divisions is central to epigenetic cell
memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and …

Gene expression programmes conferring cellular identity are achieved through the
organization of chromatin structures that either facilitate or impede transcription. Among the …