Long before van Leeuwenhoek peered through his microscope to describe bacteria in 1676,
microbial infections have been an enduring cause of human death. Although the evolution of …

D espite recent improvements in intensive care monitoring, diagnostic techniques, and
therapies, sepsis remains common among the critically ill. Moreover, related mortality rates …

Of the World Health Organization top 10 causes of death, 4 fulfill the definition of sepsis
(www. who. int). Sepsis occurs when infection results in systemic inflammation 1, 2 and is …

Pivotal sepsis clinical trials and preclinical research in 2012 are reviewed. For interventions
ranging from synthetic complex starch solutions to recombinant human activated protein C …

Because of an interplay of microbial and host factors, some patients who suffer an acute
infectious insult progress to dysfunction of organ systems distant from the infectious site …

This special edition of the Journal of Thoracic Disease (JTD) explores emerging concepts in
the management of patients with sepsis and septic shock. Sepsis has been a leading cause …

Sepsis remains a continuing challenge for the critical care physician. Each year in the
United States there are an estimated 400,000 cases of sepsis, with half being severe …

Abbreviations: ACCP= American College of Chest Physicians; APACHE= acute physiology
and chronic health evaluation; ILl= interleukin 1; iNOS= inducible nitric oxide synthase; …

NEW THERAPEUTIC APPROACHES FOR SEPSIS HAVE NOT fared well recently. In
January, Eisai announced that its worldwide phase 3 randomized trial of a novel anti–Toll …

Sepsis, like cancer, is a disease concept that can be traced back to Greece during the time
of Hippocrates [1]. Whereas cancer described a condition of abnormal growth, sepsis was …