Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish
AR Timme-Laragy, CJ Cockman, CW Matson… - Aquatic toxicology, 2007 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are pollutants created by the incomplete
combustion of carbon, and are increasing in the environment largely due to the burning of …
combustion of carbon, and are increasing in the environment largely due to the burning of …
The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish
SM Billiard, AR Timme-Laragy… - Toxicological …, 2006 - academic.oup.com
Planar halogenated aromatic hydrocarbons (pHAHs), such as 2, 3, 7, 8-tetrachlorodibenzo-p-
dioxin (dioxin), show strong binding affinity for the aryl hydrocarbon receptor (AHR) and are …
dioxin (dioxin), show strong binding affinity for the aryl hydrocarbon receptor (AHR) and are …
Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish
BC Goodale, SC Tilton, MM Corvi, GR Wilson… - Toxicology and applied …, 2013 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components
of fossil fuels and by-products of combustion. These multi-ring chemicals differentially …
of fossil fuels and by-products of combustion. These multi-ring chemicals differentially …
AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE-and ARE-associated gene induction in zebrafish (Danio rerio)
LA Van Tiem, RT Di Giulio - Toxicology and applied pharmacology, 2011 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants often
present in aquatic systems as complex mixtures. Embryonic fish are sensitive to the …
present in aquatic systems as complex mixtures. Embryonic fish are sensitive to the …
Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A …
Polycyclic aromatic hydrocarbons (PAHs) derived from fossil fuels are ubiquitous
contaminants and occur in aquatic habitats as highly variable and complex mixtures of …
contaminants and occur in aquatic habitats as highly variable and complex mixtures of …
AHR2-mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs
N Jayasundara, L Van Tiem Garner… - Toxicological …, 2015 - academic.oup.com
Polycyclic aromatic hydrocarbons (PAHs) induce developmental defects including cardiac
deformities in fish. The aryl hydrocarbon receptor (AHR) mediates the toxicity of some PAHs …
deformities in fish. The aryl hydrocarbon receptor (AHR) mediates the toxicity of some PAHs …
Aryl hydrocarbon receptor–independent toxicity of weathered crude oil during fish development
JP Incardona, MG Carls, H Teraoka… - Environmental …, 2005 - ehp.niehs.nih.gov
Polycyclic aromatic hydrocarbons (PAHs), derived largely from fossil fuels and their
combustion, are pervasive contaminants in rivers, lakes, and nearshore marine habitats …
combustion, are pervasive contaminants in rivers, lakes, and nearshore marine habitats …
Low-level pyrene exposure causes cardiac toxicity in zebrafish (Danio rerio) embryos
Y Zhang, C Wang, L Huang, R Chen, Y Chen, Z Zuo - Aquatic toxicology, 2012 - Elsevier
It is widely accepted that the most abundant polycyclic aromatic hydrocarbons (PAHs) in
weathered crude oils is cardiotoxic. Although PAHs toxic endpoints show strong correlation …
weathered crude oils is cardiotoxic. Although PAHs toxic endpoints show strong correlation …
Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in Fundulus heteroclitus
DM Wassenberg, RT Di Giulio - Environmental health …, 2004 - ehp.niehs.nih.gov
Widespread contamination of aquatic systems with polycyclic aromatic hydrocarbons (PAHs)
has led to concern about effects of PAHs on aquatic life. Some PAHs have been shown to …
has led to concern about effects of PAHs on aquatic life. Some PAHs have been shown to …
Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos
LVT Garner, DR Brown, RT Di Giulio - Aquatic toxicology, 2013 - Elsevier
Various environmental contaminants are known agonists for the aryl hydrocarbon receptor
(AHR), which is highly conserved across vertebrate species. Due to gene duplication events …
(AHR), which is highly conserved across vertebrate species. Due to gene duplication events …