Natural killer (NK) cells have high intrinsic cytotoxic capacity, and clinical trials have
demonstrated their safety and efficacy for adoptive cancer therapy. Expression of chimeric …

Abstract Background: Natural Killer (NK) cells are known for their high intrinsic cytotoxic
capacity. Recently, we and others showed that virally transduced NK cells equipped with a …

Natural killer cells are a promising platform for cancer immunotherapy. Natural killer cells
have high intrinsic killing capability, and the insertion of a chimeric antigen receptor can …

Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

Natural killer (NK) cells are a noteworthy lymphocyte subset in cancer adoptive cell therapy.
NK cells initiate innate immune responses against infections and malignancies with natural …

Natural killer (NK) cells are powerful immune effectors whose antitumor activity is regulated
through a sophisticated network of activating and inhibitory receptors. As effectors of cancer …

T lymphocytes that express an anti-CD19 chimeric antigen receptor (CAR) to redirect target
specificity exhibit remarkable remissions in B cell malignancies. However, these cells are …

Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system capable of
immune surveillance. Given their ability to rapidly and effectively recognize and kill aberrant …

Immunotherapy with T cell modified with gamma-retroviral or lentiviral (LV) vectors to
express a chimeric antigen receptor (CAR) has shown remarkable efficacy in clinical trials …

Genome engineered natural killer (NK) cell therapies are emerging as a promising cancer
immunotherapy platform with potential advantages and remaining uncertainties. Feeder …