In an effort to develop a rational approach to identify anti-cancer agents with selective
polypharmacology, we mine millions of docked protein-ligand complexes involving more …

In an effort to develop a rational approach to identify anticancer agents with selective
polypharmacology, we mined millions of docked protein− ligand complexes involving more …

Cancer is one of the major health challenges in modern times. Considering its high mortality
rate, many proteins that are linked to cancer have been targeted for therapy, with one of …

The pharmacology of drugs is often defined by more than one protein target. This property
can be exploited to use approved drugs to uncover new targets and signaling pathways in …

Background: The Epidermal Growth Factor Receptor (EGFR) is a transmembrane protein
that acts as a receptor of extracellular protein ligands of the epidermal growth factor …

Present work elucidates identification of next generation inhibitors for clinically relevant
mutations of epidermal growth factor receptor (EGFR) using structure‐based bioactive …

Although both erlotinib and gefitinib target the EGF receptor (EGFR), erlotinib is effective in
patients with EGFR wild-type or mutated tumors, whereas gefitinib is only beneficial for …

Drug treatment of epidermal growth factor receptor (EGFR) positive non-small cell lung
cancer has improved substantially by targeting activating mutations within the receptor …

Epidermal growth factor receptor (EGFR) is an important validated drug target for cancer
therapy. Some therapeutic agents targeting EGFR have been developed, however these are …

Context As a member of a large family of proteins that together regulate various aspects of
cell growth and development, the epidermal growth factor receptor (EGFR) is a validated …