An obstacle in the treatment of human diseases such as cancer is the inability to selectively
and effectively target historically undruggable targets such as transcription factors. Here, we …

With the recent comprehensive mapping of cancer genomes, there is now a need for
functional approaches to edit the aberrant epigenetic state of key cancer drivers to …

Epigenome editing is a promising technology, potentially allowing the stable reprogramming
of gene expression profiles without alteration of the DNA sequence. Targeted DNA …

Studies on biological functions of N 6-methyladenosine (m6A) modification in mRNA have
drawn significant attention in recent years. Here we describe the construction and …

DNA methylation plays a critical role in the regulation and maintenance of cell-type specific
transcriptional programs. Targeted epigenome editing is an emerging technology to …

DNA methylation is the most widely-studied epigenetic modification, playing a critical role in
the regulation of gene expression. Dysregulation of DNA methylation is implicated in the …

DNA methylation plays important roles in determining cellular identity, disease, and
environmental responses, but little is known about the mechanisms that drive methylation …

The controlled and specific re-activation of endogenous tumor suppressors in cancer cells
represents an important therapeutic strategy to block tumor growth and subsequent …

Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …

Comprehensive studies have shown that DNA methylation plays vital roles in both loss of
pluripotency and governance of the transcriptome during embryogenesis and subsequent …